2014
Risk Factors for Optic Disc Hemorrhage in the Low-Pressure Glaucoma Treatment Study
Furlanetto RL, De Moraes CG, Teng CC, Liebmann JM, Greenfield DS, Gardiner SK, Ritch R, Krupin T, Group L. Risk Factors for Optic Disc Hemorrhage in the Low-Pressure Glaucoma Treatment Study. American Journal Of Ophthalmology 2014, 157: 945-952.e1. PMID: 24513094, DOI: 10.1016/j.ajo.2014.02.009.Peer-Reviewed Original ResearchConceptsDisc hemorrhage detectionLow-pressure Glaucoma Treatment StudyOcular perfusion pressureSystolic blood pressureDisc hemorrhageRisk factorsNeuroretinal rim widthSystemic β-blockersStudy patientsBlood pressurePerfusion pressureIntraocular pressureΒ-blockersLower mean systolic blood pressureMean systolic blood pressureTreatment studiesLower systolic blood pressureCox proportional hazards modelRim widthOptic disc hemorrhageIndependent risk factorUntreated intraocular pressureHistory of migraineMulticenter clinical trialSystemic risk factorsEarly Glaucoma Involves Both Deep Local, and Shallow Widespread, Retinal Nerve Fiber Damage of the Macular RegionCircumpapillary Glaucomatous Defects
Hood DC, Slobodnick A, Raza AS, de Moraes CG, Teng CC, Ritch R. Early Glaucoma Involves Both Deep Local, and Shallow Widespread, Retinal Nerve Fiber Damage of the Macular RegionCircumpapillary Glaucomatous Defects. Investigative Ophthalmology & Visual Science 2014, 55: 632-649. PMID: 24370831, PMCID: PMC3912939, DOI: 10.1167/iovs.13-13130.Peer-Reviewed Original ResearchConceptsRetinal nerve fiber layerCircumpapillary retinal nerve fiber layerGlaucomatous damageInferior retinaRetinal nerve fiber damageOptical coherence tomography scansMacular cube scansEarly glaucomatous damageNerve fiber damageNerve fiber layerVisual field testInner plexiform layerRetinal ganglion cellsCircle scanMacular damageGlaucoma patientsSuperior retinaCube scansEarly glaucomaGanglion cellsPlexiform layerTomography scanMacular cubeVF testsFiber layer
2013
Focal Lamina Cribrosa Defects Associated With Glaucomatous Rim Thinning and Acquired Pits
You JY, Park SC, Su D, Teng CC, Liebmann JM, Ritch R. Focal Lamina Cribrosa Defects Associated With Glaucomatous Rim Thinning and Acquired Pits. JAMA Ophthalmology 2013, 131: 314-320. PMID: 23370812, DOI: 10.1001/jamaophthalmol.2013.1926.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAged, 80 and overAntihypertensive AgentsCross-Sectional StudiesFemaleFollow-Up StudiesGlaucomaHumansImage Processing, Computer-AssistedImaging, Three-DimensionalIntraocular PressureMaleMiddle AgedNerve FibersOptic DiskOptic Nerve DiseasesProspective StudiesRetinal Ganglion CellsTomography, Optical CoherenceVision DisordersVisual FieldsConceptsFocal LC defectsEDI-OCT imagesFocal lamina cribrosaNeuroretinal rim lossDisc photographsLamina cribrosaRim lossGlaucomatous optic disc changesLC defectsGlaucomatous visual field progressionGlaucoma referral practiceIrregular tear filmOptic disc changesOptic disc photographsPoor patient cooperationOptic nerve headVisual field progressionOptical coherence tomographic imagesPotential clinical importanceCross-sectional analysisAcquired pitsRim thinningOptic nerveNerve headClinical examinationOptic disc progression and rates of visual field change in treated glaucoma
De Moraes CG, Liebmann JM, Park SC, Teng CC, Nemiroff J, Tello C, Ritch R. Optic disc progression and rates of visual field change in treated glaucoma. Acta Ophthalmologica 2013, 91: e86-e91. PMID: 23356423, DOI: 10.1111/j.1755-3768.2012.02577.x.Peer-Reviewed Original ResearchConceptsOptic disc progressionVisual field changesPointwise linear regressionPrimary open-angle glaucomaRepeatable VF lossOptic disc photographsOptic disc stereophotographsMore rapid progressionOpen-angle glaucomaDB/yearSITA Standard 24Future vision lossAdjacent test pointsDisc hemorrhageAggressive therapyDisc photographsDisc stereophotographsMost patientsGlaucoma patientsGlaucoma specialistsVF lossVF progressionGlaucomatous eyesVF deteriorationAngle glaucoma
2012
Rates of visual field progression in distinct optic disc phenotypes
Schor KS, De Moraes CG, Teng CC, Tello C, Liebmann JM, Ritch R. Rates of visual field progression in distinct optic disc phenotypes. Clinical And Experimental Ophthalmology 2012, 40: 706-712. PMID: 22429789, DOI: 10.1111/j.1442-9071.2012.02792.x.Peer-Reviewed Original ResearchConceptsOptic disc phenotypesVisual field progressionOptic disc stereophotographsField progressionGeneralized enlargementDisc stereophotographsGlaucoma patientsRisk factorsVisual field mean deviationBaseline visual field mean deviationDisc phenotypesGlaucomatous visual field progressionSenile sclerotic discsRisk of progressionHigh intraocular pressureDisc hemorrhageRetrospective cohortClinical variablesIntraocular pressurePointwise linear regressionSclerotic groupDisc appearanceUnivariate analysisClinical practicePerimetric dataIn Vivo Evaluation of Focal Lamina Cribrosa Defects in Glaucoma
Kiumehr S, Park SC, Dorairaj S, Teng CC, Tello C, Liebmann JM, Ritch R. In Vivo Evaluation of Focal Lamina Cribrosa Defects in Glaucoma. JAMA Ophthalmology 2012, 130: 552-559. PMID: 22232364, DOI: 10.1001/archopthalmol.2011.1309.Peer-Reviewed Original ResearchConceptsFocal LC defectsFocal lamina cribrosaVisual field lossLamina cribrosaNeuroretinal rimOptic nerveHealthy subjectsOptic discField lossEnhanced depthLC defectsGreater sensitivity lossOptic nerve headVisual field defectsOptical coherence tomographic imagesOptical coherence tomographyNerve headField defectsHealthy eyesInferior halfGlaucomaTissue lossCoherence tomographyFar peripheryVivo evaluationHorizontal Central Ridge of the Lamina Cribrosa and Regional Differences in Laminar Insertion in Healthy Subjects
Park SC, Kiumehr S, Teng CC, Tello C, Liebmann JM, Ritch R. Horizontal Central Ridge of the Lamina Cribrosa and Regional Differences in Laminar Insertion in Healthy Subjects. Investigative Ophthalmology & Visual Science 2012, 53: 1610-1616. PMID: 22266523, DOI: 10.1167/iovs.11-7577.Peer-Reviewed Original ResearchConceptsAnterior laminar surfaceLamina cribrosaHealthy subjectsDepth Imaging Optical Coherence TomographyTemporal regionsHorizontal B-scansOptic nerve headPathophysiology of glaucomaVertical B-scansB-scansInferior midperipheryEDI-OCTNerve headLC depthCoherence tomographyPeripapillary scleraLaminar surfaceInsertion areaEyesFurther investigationSubjectsMidperipheryRegional differencesGlaucomaLC images
2011
Enhanced Depth Imaging Optical Coherence Tomography of Deep Optic Nerve Complex Structures in Glaucoma
Park SC, De Moraes CG, Teng CC, Tello C, Liebmann JM, Ritch R. Enhanced Depth Imaging Optical Coherence Tomography of Deep Optic Nerve Complex Structures in Glaucoma. Ophthalmology 2011, 119: 3-9. PMID: 21978593, DOI: 10.1016/j.ophtha.2011.07.012.Peer-Reviewed Original ResearchConceptsShort posterior ciliary arteriesCentral retinal arteryCentral retinal veinDepth Imaging Optical Coherence TomographyOptical coherence tomographyEDI-OCT imagesLamina cribrosaGlaucoma patientsOptic nerveHigh myopiaCoherence tomographyEnhanced Depth Imaging Optical Coherence TomographyOptic nerve complexOptic disc photographsPosterior ciliary arteriesFocal LC defectsAnterior laminar surfaceOCT imagesIntrachoroidal cavitationDisc photographsCiliary arteriesGlaucomatous damagePathologic featuresPeripapillary choroidRetinal arteryCorneal Hysteresis and Beta-Zone Parapapillary Atrophy
Hayes DD, Teng CC, de Moraes CG, Tello C, Liebmann JM, Ritch R. Corneal Hysteresis and Beta-Zone Parapapillary Atrophy. American Journal Of Ophthalmology 2011, 153: 358-362.e1. PMID: 21920490, DOI: 10.1016/j.ajo.2011.06.025.Peer-Reviewed Original ResearchConceptsVisual field mean deviationCorneal hysteresisCorneal resistance factorOcular Response AnalyzerCentral corneal thicknessDisc photographsParapapillary atrophySignificant differencesBeta-zone parapapillary atrophyΒ-zone parapapillary atrophyClear corneal phacoemulsificationContact lens useCross-sectional studyLens useFellow eyesGlaucoma patientsOcular surgeryCorneal abnormalitiesMasked fashionCorneal thicknessUnivariate analysisStudy visitΒPPAExclusion criteriaMultivariate analysisThe Region of Largest β-Zone Parapapillary Atrophy Area Predicts the Location of Most Rapid Visual Field Progression
Teng CC, De Moraes CG, Prata TS, Liebmann CA, Tello C, Ritch R, Liebmann JM. The Region of Largest β-Zone Parapapillary Atrophy Area Predicts the Location of Most Rapid Visual Field Progression. Ophthalmology 2011, 118: 2409-2413. PMID: 21885127, DOI: 10.1016/j.ophtha.2011.06.014.Peer-Reviewed Original ResearchConceptsΒ-zone parapapillary atrophyVisual field progressionVF progressionParapapillary atrophyDB/yearField progressionFuture VF progressionGlaucoma patientsInferior hemifieldPointwise linear regression criteriaRapid visual field progressionEnd pointOpen-angle glaucoma patientsFaster VF progressionParapapillary atrophy areaProgression end pointsOptic disc photographsMean numberGlaucoma Progression StudyDisc photographsRetrospective cohortAtrophy areaSuperior hemifieldPatientsLinear regression criteriaBeta-zone parapapillary atrophy and multifocal visual evoked potentials in eyes with glaucomatous optic neuropathy
De Moraes CG, Ketner S, Teng CC, Ehrlich JR, Raza AS, Liebmann JM, Ritch R, Hood DC. Beta-zone parapapillary atrophy and multifocal visual evoked potentials in eyes with glaucomatous optic neuropathy. Documenta Ophthalmologica 2011, 123: 43. PMID: 21735265, PMCID: PMC4469993, DOI: 10.1007/s10633-011-9280-3.Peer-Reviewed Original ResearchConceptsGlaucomatous optic neuropathyPattern standard deviationBeta-zone parapapillary atrophySAP mean deviationSpherical equivalentOptic neuropathyParapapillary atrophyOptic disc stereophotographsMean deviationMfVEP testingPerimetry abnormalitiesDisc stereophotographsMfVEP responsesUnivariate analysisRefractive errorSAP severitySAP scoreIndependent factorsSAP resultsMean latencyMultivariate modelNeuropathyEyesSignificant differencesPatientsInitial Parafoveal Versus Peripheral Scotomas in Glaucoma: Risk Factors and Visual Field Characteristics
Park SC, De Moraes CG, Teng CC, Tello C, Liebmann JM, Ritch R. Initial Parafoveal Versus Peripheral Scotomas in Glaucoma: Risk Factors and Visual Field Characteristics. Ophthalmology 2011, 118: 1782-1789. PMID: 21665283, DOI: 10.1016/j.ophtha.2011.02.013.Peer-Reviewed Original ResearchConceptsInitial parafoveal scotomaMaximum untreated intraocular pressureUntreated intraocular pressureSystemic risk factorsRisk factorsIntraocular pressureVisual fieldDisc hemorrhage detectionVF mean deviationGroup of patientsCentral corneal thicknessStandard visual fieldsVisual field characteristicsDH detectionParafoveal scotomaPeripheral scotomaCentral field lossClinical characteristicsMean deviationNasal stepCorneal thicknessRefractive errorFamily historyObservational studyHigh risk
2010
Risk Factors for Visual Field Progression in Treated Glaucoma
De Moraes CG, Juthani VJ, Liebmann JM, Teng CC, Tello C, Susanna R, Ritch R. Risk Factors for Visual Field Progression in Treated Glaucoma. JAMA Ophthalmology 2010, 129: 562-568. PMID: 21555607, DOI: 10.1001/archophthalmol.2011.72.Peer-Reviewed Original ResearchConceptsBeta-zone parapapillary atrophyVisual field progressionCentral corneal thicknessDisc hemorrhageParapapillary atrophyCorneal thicknessField progressionPeak IOPVF progressionRisk factorsBaseline VF mean deviationIOP-independent risk factorsThinner central corneal thicknessRepeatable VF lossVF mean deviationSwedish Interactive Threshold AlgorithmGlaucoma Progression StudyRetrospective cohortGlaucoma patientsIntraocular pressurePointwise linear regressionVF lossBaseline diagnosisVF examinationDisease progressionRecurrent disc hemorrhage does not increase the rate of visual field progression
de Beaufort HC, De Moraes CG, Teng CC, Prata TS, Tello C, Ritch R, Liebmann JM. Recurrent disc hemorrhage does not increase the rate of visual field progression. Graefe's Archive For Clinical And Experimental Ophthalmology 2010, 248: 839-844. PMID: 20182885, DOI: 10.1007/s00417-010-1306-0.Peer-Reviewed Original ResearchConceptsRecurrent disc hemorrhagesDisc hemorrhageDisc photographsPointwise linear regression analysisPrimary open-angle glaucomaGlaucomatous visual field lossInitial disc hemorrhagesSingle disc hemorrhagesVisual field lossOpen-angle glaucomaVisual field progressionFuture disease progressionRate of progressionNumber of eyesDH eyesMost patientsConsecutive patientsResultsOne hundredMean ageVF progressionProgression endpointDisease progressionField progressionGroup BGroup Aβ-Zone Parapapillary Atrophy and the Velocity of Glaucoma Progression
Teng CC, De Moraes CG, Prata TS, Tello C, Ritch R, Liebmann JM. β-Zone Parapapillary Atrophy and the Velocity of Glaucoma Progression. Ophthalmology 2010, 117: 909-915. PMID: 20132988, DOI: 10.1016/j.ophtha.2009.10.016.Peer-Reviewed Original ResearchConceptsBeta-zone parapapillary atrophyCentral corneal thicknessDisc area ratioParapapillary atrophyIntraocular pressureGlaucoma progressionVF progressionIOP fluctuationRim areaΒ-zone parapapillary atrophyPointwise linear regression analysisPPA areaGlaucomatous visual field progressionClose clinical surveillanceRepeatable VF lossOptic disc photographsBaseline intraocular pressureMean intraocular pressureBaseline mean deviationDiopters of myopiaVisual field testVisual field progressionGlaucoma Progression StudyDisc photographsChorioretinal atrophy
2009
Factors Affecting Rates of Visual Field Progression in Glaucoma Patients with Optic Disc Hemorrhage
Prata TS, De Moraes CG, Teng CC, Tello C, Ritch R, Liebmann JM. Factors Affecting Rates of Visual Field Progression in Glaucoma Patients with Optic Disc Hemorrhage. Ophthalmology 2009, 117: 24-29. PMID: 19896197, DOI: 10.1016/j.ophtha.2009.06.028.Peer-Reviewed Original ResearchConceptsDB/yearDisc hemorrhageOptic disc hemorrhageVisual field progressionDH detectionVF lossFaster progressionBaseline MDGlaucoma patientsRisk factorsField progressionOdds ratioPresence of DHMultivariate logistic regression analysisRetrospective cohort studyConsecutive glaucoma patientsSignificant risk factorsSwedish Interactive Threshold AlgorithmConfidence intervalsImportant risk factorRate of progressionGlaucoma Progression StudyLogistic regression analysisAggressive treatmentCohort study