2022
Overall and cause-specific hospitalisation and death after COVID-19 hospitalisation in England: A cohort study using linked primary care, secondary care, and death registration data in the OpenSAFELY platform
Bhaskaran K, Rentsch CT, Hickman G, Hulme WJ, Schultze A, Curtis HJ, Wing K, Warren-Gash C, Tomlinson L, Bates CJ, Mathur R, MacKenna B, Mahalingasivam V, Wong A, Walker AJ, Morton CE, Grint D, Mehrkar A, Eggo RM, Inglesby P, Douglas IJ, McDonald HI, Cockburn J, Williamson EJ, Evans D, Parry J, Hester F, Harper S, Evans SJ, Bacon S, Smeeth L, Goldacre B. Overall and cause-specific hospitalisation and death after COVID-19 hospitalisation in England: A cohort study using linked primary care, secondary care, and death registration data in the OpenSAFELY platform. PLOS Medicine 2022, 19: e1003871. PMID: 35077449, PMCID: PMC8789178, DOI: 10.1371/journal.pmed.1003871.Peer-Reviewed Original ResearchConceptsCOVID-19 patientsCOVID-19 hospitalisationGeneral population controlsCOVID-19 groupCOVID-19 survivorsHospital admissionHigh riskInfluenza hospitalisationsCause mortalityCohort studyInfluenza patientsPrimary careGeneral populationInitial infectionAcute coronavirus disease 2019Lower respiratory tract infectionsSevere COVID-19 outcomesLong-term adverse outcomesCOVID-19 hospital admissionsSpecific causesPopulation controlsCause-specific hospitalisationRespiratory tract infectionsCause-specific outcomesPotential risk factors
2021
Association between warfarin and COVID-19-related outcomes compared with direct oral anticoagulants: population-based cohort study
Wong A, Tomlinson L, Brown J, Elson W, Walker A, Schultze A, Morton C, Evans D, Inglesby P, MacKenna B, Bhaskaran K, Rentsch C, Powell E, Williamson E, Croker R, Bacon S, Hulme W, Bates C, Curtis H, Mehrkar A, Cockburn J, McDonald H, Mathur R, Wing K, Forbes H, Eggo R, Evans S, Smeeth L, Goldacre B, Douglas I. Association between warfarin and COVID-19-related outcomes compared with direct oral anticoagulants: population-based cohort study. Journal Of Hematology & Oncology 2021, 14: 172. PMID: 34666811, PMCID: PMC8525065, DOI: 10.1186/s13045-021-01185-0.Peer-Reviewed Original ResearchConceptsDirect oral anticoagulantsPopulation-based cohort studyCOVID-19-related outcomesSevere COVID-19Oral anticoagulantsCohort studyHazard ratioLower riskNegative control outcome analysisSevere COVID-19 diseaseNon-valvular atrial fibrillationPrimary care dataCOVID-19 outcomesCOVID-19COVID-19 diseaseNegative control outcomesDOAC usersOpenSAFELY platformWarfarin usersHospital admissionAtrial fibrillationClinical evidenceCox regressionResultsA totalOutcome analysisRisks of covid-19 hospital admission and death for people with learning disability: population based cohort study using the OpenSAFELY platform
Williamson EJ, McDonald HI, Bhaskaran K, Walker AJ, Bacon S, Davy S, Schultze A, Tomlinson L, Bates C, Ramsay M, Curtis HJ, Forbes H, Wing K, Minassian C, Tazare J, Morton CE, Nightingale E, Mehrkar A, Evans D, Inglesby P, MacKenna B, Cockburn J, Rentsch CT, Mathur R, Wong AYS, Eggo RM, Hulme W, Croker R, Parry J, Hester F, Harper S, Douglas IJ, Evans SJW, Smeeth L, Goldacre B, Kuper H. Risks of covid-19 hospital admission and death for people with learning disability: population based cohort study using the OpenSAFELY platform. The BMJ 2021, 374: n1592. PMID: 34261639, PMCID: PMC8278652, DOI: 10.1136/bmj.n1592.Peer-Reviewed Original ResearchConceptsCovid-19 related hospital admissionRelated hospital admissionsNon-COVID deathsHospital admissionOpenSAFELY platformDown syndromeCohort studyHazard ratioCerebral palsyDisability registersGeneral practiceCOVID-19COVID-19 hospital admissionsMain exposure groupsCOVID-19 vaccinationHospital admission dataPatient-level dataLow event ratesNon-COVID causesCOVID-19 testingTargeted preventive measuresWave 2Wave 1Electronic health recordsProfound learning disabilitiesAssociation between living with children and outcomes from covid-19: OpenSAFELY cohort study of 12 million adults in England
Forbes H, Morton CE, Bacon S, McDonald HI, Minassian C, Brown JP, Rentsch CT, Mathur R, Schultze A, DeVito NJ, MacKenna B, Hulme WJ, Croker R, Walker AJ, Williamson EJ, Bates C, Mehrkar A, Curtis HJ, Evans D, Wing K, Inglesby P, Drysdale H, Wong AYS, Cockburn J, McManus R, Parry J, Hester F, Harper S, Douglas IJ, Smeeth L, Evans SJW, Bhaskaran K, Eggo RM, Goldacre B, Tomlinson LA. Association between living with children and outcomes from covid-19: OpenSAFELY cohort study of 12 million adults in England. The BMJ 2021, 372: n628. PMID: 33737413, PMCID: PMC7970340, DOI: 10.1136/bmj.n628.Peer-Reviewed Original ResearchConceptsSARS-CoV-2 infectionIntensive care admissionHospital admissionCare admissionCohort studyCOVID-19Covid-19 related hospital admissionSevere acute respiratory syndrome coronavirus 2Acute respiratory syndrome coronavirus 2Respiratory syndrome coronavirus 2Wave 2Primary care dataRelated hospital admissionsSyndrome coronavirus 2Adults 65 yearsCohort of adultsCOVID-19 outcomesCoronavirus disease 2019COVID-19 mortalityRisk of infectionWave 1UK pandemicHazard ratioIntensive careAbsolute riskUK prevalence of underlying conditions which increase the risk of severe COVID-19 disease: a point prevalence study using electronic health records
Walker JL, Grint DJ, Strongman H, Eggo RM, Peppa M, Minassian C, Mansfield KE, Rentsch CT, Douglas IJ, Mathur R, Wong AYS, Quint JK, Andrews N, Bernal JL, Scott JA, Ramsay M, Smeeth L, McDonald HI. UK prevalence of underlying conditions which increase the risk of severe COVID-19 disease: a point prevalence study using electronic health records. BMC Public Health 2021, 21: 484. PMID: 33706738, PMCID: PMC7948667, DOI: 10.1186/s12889-021-10427-2.Peer-Reviewed Original ResearchConceptsSevere COVID-19Health conditionsElectronic health recordsHigh riskRisk populationsCOVID-19Clinical Practice Research Datalink GOLDSevere COVID-19 diseaseSecondary care recordsChronic kidney diseaseHealth recordsChronic liver diseasePoint prevalence studyBinomial exact confidence intervalsOlder age groupsPublic health interventionsWorking-aged individualsCOVID-19 diseaseWorking-aged adultsUK prevalenceCurrent asthmaLiver diseaseCancer survivorsPoint prevalenceKidney disease
2020
HIV infection and COVID-19 death: a population-based cohort analysis of UK primary care data and linked national death registrations within the OpenSAFELY platform
Bhaskaran K, Rentsch CT, MacKenna B, Schultze A, Mehrkar A, Bates CJ, Eggo RM, Morton CE, Bacon SCJ, Inglesby P, Douglas IJ, Walker AJ, McDonald HI, Cockburn J, Williamson EJ, Evans D, Forbes HJ, Curtis HJ, Hulme WJ, Parry J, Hester F, Harper S, Evans SJW, Smeeth L, Goldacre B. HIV infection and COVID-19 death: a population-based cohort analysis of UK primary care data and linked national death registrations within the OpenSAFELY platform. The Lancet HIV 2020, 8: e24-e32. PMID: 33316211, PMCID: PMC7773630, DOI: 10.1016/s2352-3018(20)30305-2.Peer-Reviewed Original ResearchConceptsCOVID-19 deathsNational death registrationsPrimary care dataHazard ratioHIV infectionOpenSAFELY platformBlack ethnicityHealth Research Oxford Biomedical Research CentreElectronic primary care dataPopulation-based cohort analysisDeath registrationUK primary care dataCare dataLarge-scale population-based studyRetrospective cohort studyPrimary care recordsUK Medical Research CouncilPopulation-based studyRisk of deathHealth Data Research UKNon-black individualsNational InstituteCOVID-19 mortalityMedical Research CouncilBiomedical Research CentreCOVID-19 in Great Britain: epidemiological and clinical characteristics of the first few hundred (FF100) cases: a descriptive case series and case control analysis
Boddington N, Charlett A, Elgohari S, Walker J, McDonald H, Byers C, Coughlan L, Vilaplana T, Whillock R, Sinnathamby M, Panagiotopoulos N, Letley L, MacDonald P, Vivancos R, Edeghere O, Shingleton J, Bennett E, Grint D, Strongman H, Mansfield K, Rentsch C, Minassian C, Douglas I, Mathur R, Peppa M, Cottrell S, McMenamin J, Zambon M, Ramsay M, Dabrera G, Saliba V, Bernal J. COVID-19 in Great Britain: epidemiological and clinical characteristics of the first few hundred (FF100) cases: a descriptive case series and case control analysis. Bulletin Of The World Health Organization 2020, 99: 178-189. PMID: 33716340, PMCID: PMC7941108, DOI: 10.2471/blt.20.265603.Peer-Reviewed Original ResearchConceptsProportion of COVID-19 casesPredictive value of symptomsTraining public health professionalsHealth-care seeking behaviorOccurrence of feverCase-control analysisCourse of diseaseSpecificity of symptomsShortness of breathPublic health professionalsProportion of childrenClinical presentationClinical characteristicsExposure to infectionRespiratory infectionsCases of coronavirus disease 2019Household contactsHealth professionalsBurden of COVID-19Predictive valueCase definitionCoronavirus disease 2019COVID-19 casesControl groupFeverRisk of COVID-19-related death among patients with chronic obstructive pulmonary disease or asthma prescribed inhaled corticosteroids: an observational cohort study using the OpenSAFELY platform
Schultze A, Walker AJ, MacKenna B, Morton CE, Bhaskaran K, Brown JP, Rentsch CT, Williamson E, Drysdale H, Croker R, Bacon S, Hulme W, Bates C, Curtis HJ, Mehrkar A, Evans D, Inglesby P, Cockburn J, McDonald HI, Tomlinson L, Mathur R, Wing K, Wong AYS, Forbes H, Parry J, Hester F, Harper S, Evans SJW, Quint J, Smeeth L, Douglas IJ, Goldacre B, Collaborative O. Risk of COVID-19-related death among patients with chronic obstructive pulmonary disease or asthma prescribed inhaled corticosteroids: an observational cohort study using the OpenSAFELY platform. The Lancet Respiratory Medicine 2020, 8: 1106-1120. PMID: 32979987, PMCID: PMC7515601, DOI: 10.1016/s2213-2600(20)30415-x.Peer-Reviewed Original ResearchMeSH KeywordsAdministration, InhalationAdolescentAdrenal Cortex HormonesAdultAgedAged, 80 and overAsthmaBetacoronavirusCohort StudiesCoronavirus InfectionsCOVID-19Electronic Health RecordsEnglandFemaleHumansMaleMiddle AgedMuscarinic AntagonistsPandemicsPneumonia, ViralProportional Hazards ModelsPulmonary Disease, Chronic ObstructiveRegression AnalysisSARS-CoV-2Young AdultConceptsChronic obstructive pulmonary diseaseCOVID-19-related deathsIndex dateObstructive pulmonary diseaseElectronic health recordsOpenSAFELY platformRespiratory medicationsCOPD cohortHazard ratioPulmonary diseaseAsthma cohortPrimary care electronic health recordsSevere acute respiratory syndrome coronavirus 2Acute respiratory syndrome coronavirus 2Respiratory syndrome coronavirus 2High-dose ICSHigh-dose ICSsRegular ICS useΒ-agonistsObservational cohort studyUK Medical Research CouncilRisk of deathCox regression modelAcute respiratory diseaseSyndrome coronavirus 2Factors associated with COVID-19-related death using OpenSAFELY
Williamson EJ, Walker AJ, Bhaskaran K, Bacon S, Bates C, Morton CE, Curtis HJ, Mehrkar A, Evans D, Inglesby P, Cockburn J, McDonald HI, MacKenna B, Tomlinson L, Douglas IJ, Rentsch CT, Mathur R, Wong AYS, Grieve R, Harrison D, Forbes H, Schultze A, Croker R, Parry J, Hester F, Harper S, Perera R, Evans SJW, Smeeth L, Goldacre B. Factors associated with COVID-19-related death using OpenSAFELY. Nature 2020, 584: 430-436. PMID: 32640463, PMCID: PMC7611074, DOI: 10.1038/s41586-020-2521-4.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAge DistributionAge FactorsAgedAged, 80 and overAgingAsian PeopleAsthmaBetacoronavirusBlack PeopleCohort StudiesCoronavirus InfectionsCOVID-19Diabetes MellitusFemaleHumansHypertensionMaleMiddle AgedPandemicsPneumonia, ViralProportional Hazards ModelsRisk AssessmentSARS-CoV-2Sex CharacteristicsSmokingState MedicineYoung AdultConceptsCOVID-19-related deathsPrimary care electronic health recordsPrimary care recordsLarge cohort studyCoronavirus disease 2019Electronic health recordsSevere asthmaCohort studyClinical factorsSouth Asian peopleSevere outcomesDisease 2019Medical conditionsHigh riskOpenSAFELYWhite ethnicityCare recordsNHS EnglandPatient recordsPatient dataHealth recordsDeathGreater ageAsian peopleRisk
2018
Impact of linkage quality on inferences drawn from analyses using data with high rates of linkage errors in rural Tanzania
Rentsch CT, Harron K, Urassa M, Todd J, Reniers G, Zaba B. Impact of linkage quality on inferences drawn from analyses using data with high rates of linkage errors in rural Tanzania. BMC Medical Research Methodology 2018, 18: 165. PMID: 30526518, PMCID: PMC6288858, DOI: 10.1186/s12874-018-0632-5.Peer-Reviewed Original ResearchLinkage to care and antiretroviral therapy initiation by testing modality among individuals newly diagnosed with HIV in Tanzania, 2014–2017
Rentsch CT, Wringe A, Machemba R, Michael D, Urassa M, Todd J, Reniers G, Zaba B. Linkage to care and antiretroviral therapy initiation by testing modality among individuals newly diagnosed with HIV in Tanzania, 2014–2017. Tropical Medicine And International Health 2018, 23: 1384-1393. PMID: 30282113, PMCID: PMC6334504, DOI: 10.1111/tmi.13153.Peer-Reviewed Original ResearchConceptsFacility-based VCTAntiretroviral therapy initiationTherapy initiationAntenatal clinicFacility-based HIV testingInitial CD4 cell countART initiation ratesCommunity-based HTCFacility-based HTCHIV serological testingCD4 cell countInitial CD4 countNew HIV diagnosesHIV-positive individualsRural Tanzanian communityCD4 countHIV diagnosisHIV testingSerological testingEarly diagnosisCell countLinkage rateRural wardsCells/HIV
2014
Minority Stress in the Lives of Men Who Have Sex With Men in Cape Town, South Africa
McAdams-Mahmoud A, Stephenson R, Rentsch C, Cooper H, Arriola KJ, Jobson G, de Swardt G, Struthers H, McIntyre J. Minority Stress in the Lives of Men Who Have Sex With Men in Cape Town, South Africa. Journal Of Homosexuality 2014, 61: 847-867. PMID: 24392722, DOI: 10.1080/00918369.2014.870454.Peer-Reviewed Original Research
2012
Attitudes Toward Couples-Based HIV Counseling and Testing Among MSM in Cape Town, South Africa
Stephenson R, Rentsch C, Sullivan P, McAdams-Mahmoud A, Jobson G, Struthers H, McIntyre J. Attitudes Toward Couples-Based HIV Counseling and Testing Among MSM in Cape Town, South Africa. AIDS And Behavior 2012, 17: 43-50. PMID: 22961498, PMCID: PMC3529975, DOI: 10.1007/s10461-012-0293-z.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedAttitudeCounselingFamily CharacteristicsFocus GroupsHIV InfectionsHomosexuality, MaleHumansMaleMass ScreeningMiddle AgedPatient Acceptance of Health CareQualitative ResearchRisk Reduction BehaviorRisk-TakingSexual PartnersSocial SupportSouth AfricaSurveys and QuestionnairesTrustUrban PopulationYoung Adult