2023
Effects of topiramate therapy on serum bicarbonate concentration in a sample of 10,279 veterans
Naps M, Leong S, Hartwell E, Rentsch C, Kranzler H. Effects of topiramate therapy on serum bicarbonate concentration in a sample of 10,279 veterans. Alcohol Clinical And Experimental Research 2023, 47: 438-447. PMID: 36810985, DOI: 10.1111/acer.15011.Peer-Reviewed Original ResearchConceptsSerum bicarbonate concentrationAlcohol use disorderMetabolic acidosisMEq/LAlcohol consumptionTopiramate therapyAlcohol Use Disorders Identification Test-Consumption scoresVeterans Health Administration electronic health record dataBicarbonate concentrationPropensity score-matched control groupPropensity score-matched controlsMean daily dosageSignificant metabolic acidosisElectronic health record dataDiagnosis of AUDHealth record dataBaseline alcohol consumptionDifferences linear regression modelThree-level measureAcid-base balanceTopiramate dosageTopiramate prescriptionsMean followTopiramate treatmentDaily dosage
2022
Association of topiramate prescribed for any indication with reduced alcohol consumption in electronic health record data
Kranzler HR, Leong SH, Naps M, Hartwell EE, Fiellin DA, Rentsch CT. Association of topiramate prescribed for any indication with reduced alcohol consumption in electronic health record data. Addiction 2022, 117: 2826-2836. PMID: 35768956, PMCID: PMC10317468, DOI: 10.1111/add.15980.Peer-Reviewed Original ResearchConceptsAUDIT-C scoresAlcohol use disorderElectronic health record dataHealth record dataUse disordersNEG patientsTopiramate dosageAlcohol Use Disorders Identification Test-Consumption scoresPropensity score-matched groupsHistory of AUDParallel group comparisonPropensity score-matched comparison groupRecord dataBaseline drinking levelsReduced alcohol consumptionHealth care systemTopiramate prescriptionsPre-post differencesAUD historyTopiramate's effectsPatientsRecord diagnosisAlcohol consumptionTopiramateComparison group