2024
A Mendelian randomization study of alcohol use and cardiometabolic disease risk in a multi‐ancestry population from the Million Veteran Program
Kember R, Rentsch C, Lynch J, Vujkovic M, Voight B, Justice A, Program M, Assimes T, Kranzler H. A Mendelian randomization study of alcohol use and cardiometabolic disease risk in a multi‐ancestry population from the Million Veteran Program. Alcohol Clinical And Experimental Research 2024 PMID: 39580711, DOI: 10.1111/acer.15445.Peer-Reviewed Original ResearchCoronary heart diseaseMR analysisMillion Veteran ProgramGenetic scoreAlcohol consumptionBody mass indexMendelian randomizationCardiometabolic diseasesVeteran ProgramAfrican AmericansAlcohol Use Disorders Identification Test-Consumption (AUDIT-C) scoresEuropean AmericansHispanic AmericansAssociation of alcohol consumptionMultivariable MR analysisAssociated with CHD riskMendelian randomization studiesRisk of cardiometabolic diseasesAssociated with alcohol consumptionCardiometabolic disease riskIncidence of coronary heart diseaseObservational studyNested case-control studyReduced risk of cardiometabolic diseasesMulti-ancestry population
2021
Relationship Between Glycemia and Cognitive Function, Structural Brain Outcomes, and Dementia: A Mendelian Randomization Study in the UK Biobank.
Garfield V, Farmaki AE, Fatemifar G, Eastwood SV, Mathur R, Rentsch CT, Denaxas S, Bhaskaran K, Smeeth L, Chaturvedi N. Relationship Between Glycemia and Cognitive Function, Structural Brain Outcomes, and Dementia: A Mendelian Randomization Study in the UK Biobank. Diabetes 2021, 70: 2313-2321. PMID: 33632741, DOI: 10.2337/db20-0895.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedBiological Specimen BanksBlood GlucoseBrainCognitionDementiaDiabetes Mellitus, Type 2FemaleGenome-Wide Association StudyGlycated HemoglobinHumansMaleMemoryMendelian Randomization AnalysisMiddle AgedOrgan SizePolymorphism, Single NucleotidePrognosisReaction TimeRisk FactorsUnited KingdomWhite MatterConceptsWhite matter hyperintensity volumeType 2 diabetesHippocampal volumeAlzheimer's dementiaRisk of ADCognitive functionMendelian randomizationBrain structuresStructural brain outcomesGenetic instrumentsMR sensitivity analysesUK BiobankVisual memoryMendelian randomization studyIncident dementiaBrain outcomesDiabetes riskHyperintensity volumeMeasures of cognitionPeripheral glycemiaBidirectional Mendelian randomizationDiabetesRandomization studyCausal associationGlycemia