2021
Factors associated with deaths due to COVID-19 versus other causes: population-based cohort analysis of UK primary care data and linked national death registrations within the OpenSAFELY platform
Bhaskaran K, Bacon S, Evans SJ, Bates CJ, Rentsch CT, MacKenna B, Tomlinson L, Walker AJ, Schultze A, Morton CE, Grint D, Mehrkar A, Eggo RM, Inglesby P, Douglas IJ, McDonald HI, Cockburn J, Williamson EJ, Evans D, Curtis HJ, Hulme WJ, Parry J, Hester F, Harper S, Spiegelhalter D, Smeeth L, Goldacre B. Factors associated with deaths due to COVID-19 versus other causes: population-based cohort analysis of UK primary care data and linked national death registrations within the OpenSAFELY platform. The Lancet Regional Health - Europe 2021, 6: 100109. PMID: 33997835, PMCID: PMC8106239, DOI: 10.1016/j.lanepe.2021.100109.Peer-Reviewed Original ResearchNon-COVID deathsCOVID-19 deathsNational death registrationsPrimary care dataOpenSAFELY platformCOVID-19Health Research Oxford Biomedical Research CentrePopulation-based cohort analysisDeath registrationUK primary care dataCare dataPre-existing medical conditionsCOVID-19 mortality riskChronic liver diseaseHistory of cancerUK Medical Research CouncilHealth Data Research UKNational InstituteCOVID-19 mortalityMagnitude of associationMedical Research CouncilNon-white ethnic groupsBiomedical Research CentreCohort studyLiver disease
2020
Risk of 16 cancers across the full glycemic spectrum: a population-based cohort study using the UK Biobank
Rentsch CT, Farmer RE, Eastwood SV, Mathur R, Garfield V, Farmaki AE, Bhaskaran K, Chaturvedi N, Smeeth L. Risk of 16 cancers across the full glycemic spectrum: a population-based cohort study using the UK Biobank. BMJ Open Diabetes Research & Care 2020, 8: e001600. PMID: 32859587, PMCID: PMC7454242, DOI: 10.1136/bmjdrc-2020-001600.Peer-Reviewed Original ResearchConceptsCancer riskGlycemic spectrumIncident cancerPancreatic cancerBreast cancerPopulation-based cohort studyAge-standardized incidence ratesCox proportional hazards modelPostmenopausal breast cancerPremenopausal breast cancerHistory of cancerIndependent positive associationProportional hazards modelUK cancer registriesUK BiobankEdition diagnostic codesBaseline HbA1cDiabetes medicationsMultivariable adjustmentCohort studyCancer RegistryRisk factorsDiagnostic codesIncidence rateInverse association