Relationship Between Glycemia and Cognitive Function, Structural Brain Outcomes, and Dementia: A Mendelian Randomization Study in the UK Biobank.
Garfield V, Farmaki AE, Fatemifar G, Eastwood SV, Mathur R, Rentsch CT, Denaxas S, Bhaskaran K, Smeeth L, Chaturvedi N. Relationship Between Glycemia and Cognitive Function, Structural Brain Outcomes, and Dementia: A Mendelian Randomization Study in the UK Biobank. Diabetes 2021, 70: 2313-2321. PMID: 33632741, DOI: 10.2337/db20-0895.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedBiological Specimen BanksBlood GlucoseBrainCognitionDementiaDiabetes Mellitus, Type 2FemaleGenome-Wide Association StudyGlycated HemoglobinHumansMaleMemoryMendelian Randomization AnalysisMiddle AgedOrgan SizePolymorphism, Single NucleotidePrognosisReaction TimeRisk FactorsUnited KingdomWhite MatterConceptsWhite matter hyperintensity volumeType 2 diabetesHippocampal volumeAlzheimer's dementiaRisk of ADCognitive functionMendelian randomizationBrain structuresStructural brain outcomesGenetic instrumentsMR sensitivity analysesUK BiobankVisual memoryMendelian randomization studyIncident dementiaBrain outcomesDiabetes riskHyperintensity volumeMeasures of cognitionPeripheral glycemiaBidirectional Mendelian randomizationDiabetesRandomization studyCausal associationGlycemiaHbA1c and brain health across the entire glycaemic spectrum
Garfield V, Farmaki A, Eastwood SV, Mathur R, Rentsch CT, Bhaskaran K, Smeeth L, Chaturvedi N. HbA1c and brain health across the entire glycaemic spectrum. Diabetes Obesity And Metabolism 2021, 23: 1140-1149. PMID: 33464682, PMCID: PMC8261644, DOI: 10.1111/dom.14321.Peer-Reviewed Original ResearchConceptsVascular dementiaHippocampal volumeGlycaemic spectrumBrain healthWMH volumeAlzheimer's dementiaAD riskCognitive declineWhite matter hyperintensity volumeIncident vascular dementiaLower WMH volumeHigher WMH volumeGreater hippocampal volumeBrain health outcomesLower hippocampal volumeUK Biobank cohortGlycaemic categoriesKnown diabetesAntihypertensive medicationsHbA1c levelsCause dementiaCertain cardiovascular drugsExcess riskNormoglycaemic individualsHyperintensity volume