2024
Alterations in the Skin Microbiome in Dermatologic Diseases and with External Exposures: CME Part 2
MacGibeny M, Adjei S, Pyle H, Bunick C, Ghannoum M, Grada A, Harris-Tryon T, Tyring S, Kong H. Alterations in the Skin Microbiome in Dermatologic Diseases and with External Exposures: CME Part 2. Journal Of The American Academy Of Dermatology 2024 PMID: 39173885, DOI: 10.1016/j.jaad.2024.07.1499.Peer-Reviewed Original ResearchThe Human Skin Microbiome in Health: CME Part 1
MacGibeny M, Adjei S, Pyle H, Bunick C, Ghannoum M, Grada A, Harris-Tryon T, Tyring S, Kong H. The Human Skin Microbiome in Health: CME Part 1. Journal Of The American Academy Of Dermatology 2024 PMID: 39168311, DOI: 10.1016/j.jaad.2024.07.1498.Peer-Reviewed Original ResearchHuman skin microbiomeSkin microbiomeMicrobiome-host interactionsMicrobiome-based therapiesMyriad of microorganismsMicrobial ecologyCommensal microbesMicrobiomeMicrobiome alterationsOverall homeostasisAssociated with skin diseasesMicroorganismsIn vitroIntrinsic factorsCME seriesFungiMicrobesAnimal studiesSkin healthBacteriaSkin diseasesEcologyHomeostasisSkinHuman skinAltered skin microbiome, inflammation, and JAK/STAT signaling in Southeast Asian ichthyosis patients
Ho M, Nguyen H, Van Hoang M, Bui T, Vu B, Dinh T, Vo H, Blaydon D, Eldirany S, Bunick C, Bui C. Altered skin microbiome, inflammation, and JAK/STAT signaling in Southeast Asian ichthyosis patients. Human Genomics 2024, 18: 38. PMID: 38627868, PMCID: PMC11022333, DOI: 10.1186/s40246-024-00603-x.Peer-Reviewed Original ResearchConceptsSkin microbiomeCI patientsJAK/STAT-signaling pathwayRecurrent pathogenic variantsMeta-genomeCommensal microbiotaHereditary skin disordersJAK/STAT signalingIncreased production of inflammatory cytokinesIncreased susceptibility to infectionJAK/STAT-signalingPeripheral blood mononuclear cellsPathogenic variantsAge- and gender-matched controlsSkin barrier defectsHigher colonizationResultsThis case-control studyProduction of inflammatory cytokinesMicrobial populationsBlood mononuclear cellsImproving therapeutic managementEpidermal scalesCase-control studyMicrobiomeGender-matched controls
2023
Sarecycline inhibits protein translation in Cutibacterium acnes 70S ribosome using a two-site mechanism
Lomakin I, Devarkar S, Patel S, Grada A, Bunick C. Sarecycline inhibits protein translation in Cutibacterium acnes 70S ribosome using a two-site mechanism. Nucleic Acids Research 2023, 51: 2915-2930. PMID: 36864821, PMCID: PMC10085706, DOI: 10.1093/nar/gkad103.Peer-Reviewed Original Research
2022
Sarecycline Demonstrated Reduced Activity Compared to Minocycline against Microbial Species Representing Human Gastrointestinal Microbiota
Ghannoum MA, Long L, Bunick CG, Del Rosso JQ, Gamal A, Tyring SK, McCormick TS, Grada A. Sarecycline Demonstrated Reduced Activity Compared to Minocycline against Microbial Species Representing Human Gastrointestinal Microbiota. Antibiotics 2022, 11: 324. PMID: 35326788, PMCID: PMC8944611, DOI: 10.3390/antibiotics11030324.Peer-Reviewed Original ResearchMinimum inhibitory concentrationVitro minimum inhibitory concentrationHigh minimum inhibitory concentrationsTetracycline-class antibioticsTime-kill assaysBroad-spectrum tetracycline antibioticTime-kill kinetic assayGastrointestinal tract microbiotaHigh MIC valuesHuman gastrointestinal microbiotaLess activityAcne treatmentGut microbiotaMinocyclineGut microbiomeGastrointestinal microbiotaSarecyclineInhibitory concentrationGut microorganismsSkin microbiomeVivo testingReduced activityMicrobiotaMIC valuesAntibiotics