2024
A Divergent Synthesis of Numerous Pyrroloiminoquinone Alkaloids Identifies Promising Antiprotozoal Agents
Barnes G, Magann N, Perrotta D, Hörmann F, Fernandez S, Vydyam P, Choi J, Prudhomme J, Neal A, Le Roch K, Mamoun C, Vanderwal C. A Divergent Synthesis of Numerous Pyrroloiminoquinone Alkaloids Identifies Promising Antiprotozoal Agents. Journal Of The American Chemical Society 2024, 146: 29883-29894. PMID: 39412402, PMCID: PMC11528414, DOI: 10.1021/jacs.4c11897.Peer-Reviewed Original ResearchNatural productsLarock indole synthesisAlkaloid natural productsAmine nucleophilesDivergent synthesisIndole synthesisPyrrolic nitrogenMethoxy groupLead compoundsDrug discoveryCompoundsStructural analogsPlasmodium falciparum</i>SynthesisPyrroloiminoquinoneHuman cytotoxicityMalaria parasitesNucleophilesPyrroleAntiprotozoal agentsAminesMammalian cellsIntermediate
2017
Antimalarial Properties of Simplified Kalihinol Analogues
Daub ME, Prudhomme J, Mamoun C, Le Roch KG, Vanderwal CD. Antimalarial Properties of Simplified Kalihinol Analogues. ACS Medicinal Chemistry Letters 2017, 8: 355-360. PMID: 28337330, PMCID: PMC5346982, DOI: 10.1021/acsmedchemlett.7b00013.Peer-Reviewed Original ResearchNatural productsIsonitrile functional groupsPrevious total synthesisTotal synthesisFunctional groupsRepresentative compoundsReasonable stabilitySimple analogCompoundsAntimalarial propertiesAntimalarial activityAntimalarial agentsPotent activityAnaloguesInherent liabilitySclareolidePotent inhibitorSynthesisProductsScaffoldsKalihinolsStabilityAgentsProperties