2023
FT-GPI, a highly sensitive and accurate predictor of GPI-anchored proteins, reveals the composition and evolution of the GPI proteome in Plasmodium species
Sauer L, Canovas R, Roche D, Shams-Eldin H, Ravel P, Colinge J, Schwarz R, Ben Mamoun C, Rivals E, Cornillot E. FT-GPI, a highly sensitive and accurate predictor of GPI-anchored proteins, reveals the composition and evolution of the GPI proteome in Plasmodium species. Malaria Journal 2023, 22: 27. PMID: 36698187, PMCID: PMC9876418, DOI: 10.1186/s12936-022-04430-0.Peer-Reviewed Original ResearchConceptsGPI-APsOrder HaemosporidaGPI-APSequence diversityNew protein candidatesHost cell invasionHost-pathogen interactionsPlasmodium speciesGene duplicationHydrophobic helicesGPI anchorPlasma membraneDeletion eventsProtein candidatesProteomeCell invasionHaemosporidaProteinMalaria parasitesKey functionsDiverse groupSal-1ParasitesMalaria vaccine candidateSpecies
2012
Sequencing of the smallest Apicomplexan genome from the human pathogen Babesia microti†
Cornillot E, Hadj-Kaddour K, Dassouli A, Noel B, Ranwez V, Vacherie B, Augagneur Y, Brès V, Duclos A, Randazzo S, Carcy B, Debierre-Grockiego F, Delbecq S, Moubri-Ménage K, Shams-Eldin H, Usmani-Brown S, Bringaud F, Wincker P, Vivarès CP, Schwarz RT, Schetters TP, Krause PJ, Gorenflot A, Berry V, Barbe V, Mamoun C. Sequencing of the smallest Apicomplexan genome from the human pathogen Babesia microti†. Nucleic Acids Research 2012, 40: 9102-9114. PMID: 22833609, PMCID: PMC3467087, DOI: 10.1093/nar/gks700.Peer-Reviewed Original ResearchConceptsGenome-wide phylogenetic analysisLateral transfer eventsSmallest nuclear genomesGenome-scale reconstructionB. microtiMinimal metabolic requirementsApicomplexan genomesMitochondrial genomeNuclear genomeProtozoan parasitismMultigene familyApicomplexan parasitesPhylum ApicomplexaPhylogenetic analysisNew cladeGenomeGenomic sequencingCopy numberTransfer eventsApicomplexaMetabolic requirementsBabesia microtiSequencingSpeciesProtozoa