2020
Effects of early ketamine exposure on cerebral gray matter volume and functional connectivity
Hung CC, Liu YH, Huang CC, Chou CY, Chen CM, Duann JR, Li CR, Lee TS, Lin CP. Effects of early ketamine exposure on cerebral gray matter volume and functional connectivity. Scientific Reports 2020, 10: 15488. PMID: 32968108, PMCID: PMC7512006, DOI: 10.1038/s41598-020-72320-z.Peer-Reviewed Original ResearchConceptsGray matter volumeCerebral gray matter volumeKetamine exposureFunctional connectivityMatter volumeKetamine usersBrain structuresLower gray matter volumeFunctional brain changesTreatment of depressionAdolescent-onset groupCerebral functional organizationHigher functional connectivitySuperior frontal gyrusInferior parietal lobuleMedial orbitofrontal cortexSeed-based correlation analysisKetamine groupBrain changesKetamine abuseLarge cohortRight insulaLeft precuneusKetamine misuseRight precuneus
2019
Striatal functional connectivity in chronic ketamine users: a pilot study
Hung CC, Zhang S, Chen CM, Duann JR, Lin CP, Lee TS, Li CR. Striatal functional connectivity in chronic ketamine users: a pilot study. The American Journal Of Drug And Alcohol Abuse 2019, 46: 31-43. PMID: 31264888, PMCID: PMC8627683, DOI: 10.1080/00952990.2019.1624764.Peer-Reviewed Original ResearchConceptsDuration of useChronic ketamine usersKetamine usersKetamine useKetamine misuseOrbitofrontal cortexFunctional connectivityStriatal functional connectivityState functional connectivityLeft orbitofrontal cortexBIS-11 scoresDorsal anterior cingulate cortexVoxel-wise connectivityAnterior cingulate cortexMagnetic resonance imagingOFC connectivityHealthy controlsBilateral cerebellumStriatal connectivityCingulate cortexResonance imagingControl dysfunctionVentral striatumZ-scorePilot study