2024
Lipid osmosis, membrane tension, and other mechanochemical driving forces of lipid flow
Zhang Y, Lin C. Lipid osmosis, membrane tension, and other mechanochemical driving forces of lipid flow. Current Opinion In Cell Biology 2024, 88: 102377. PMID: 38823338, PMCID: PMC11193448, DOI: 10.1016/j.ceb.2024.102377.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsMembrane tensionLipid transportNonvesicular lipid transportLipid transfer proteinsOrganelle biogenesisLipid transferMembrane proteinsMembrane domainsLipid homeostasisBiological functionsLipid flowMembrane protein densityTransfer proteinMembrane regionsProtein densityProteinMembraneLipidBiogenesisOrganelles
2022
Frame-Guided Assembly of Amphiphiles
Dong Y, Yang Y, Lin C, Liu D. Frame-Guided Assembly of Amphiphiles. Accounts Of Chemical Research 2022, 55: 1938-1948. PMID: 35786832, DOI: 10.1021/acs.accounts.2c00234.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsFrame-guided assemblyMolecular structureAssembly of amphiphilesArrangement of moleculesTraditional chemical industryMembrane protein incorporationProtein-lipid bilayerAmphiphilic assembliesAssembly morphologyAmphiphile assembliesFunctional nanomaterialsVersatile strategyAqueous environmentHydrophobic groupsHydrophobic moleculesFull surface areaHydrophobic interactionsAmphiphilesDrug deliveryMembrane proteinsFunctional complexAmphiphile concentrationAssembly strategyEPR effectNanomaterials
2015
Controlled Co-reconstitution of Multiple Membrane Proteins in Lipid Bilayer Nanodiscs Using DNA as a Scaffold
Raschle T, Lin C, Jungmann R, Shih WM, Wagner G. Controlled Co-reconstitution of Multiple Membrane Proteins in Lipid Bilayer Nanodiscs Using DNA as a Scaffold. ACS Chemical Biology 2015, 10: 2448-2454. PMID: 26356202, PMCID: PMC4769731, DOI: 10.1021/acschembio.5b00627.Peer-Reviewed Original ResearchConceptsMembrane protein complexesMultiple membrane proteinsVoltage-gated anion channelsMembrane proteinsProtein complexesHeterotrimeric membrane protein complexIndividual membrane proteinsLipid bilayer nanodiscsSingle nanodiscBilayer nanodiscsProtein aggregationMembrane environmentAnion channelNanodiscsProteinLipid bilayersModel systemProof of principleOligonucleotide sequencesComplementary oligonucleotide sequencesComplexesTemporary attachmentDNASequenceBilayers