2004
A Role for Tumor Necrosis Factor-&agr;-Mediated Endothelial Apoptosis in the Development of Experimental Idiopathic Pneumonia Syndrome
Gerbitz A, Nickoloff B, Olkiewicz K, Willmarth N, Hildebrandt G, Liu C, Kobzik L, Eissner G, Holler E, Ferrara J, Cooke K. A Role for Tumor Necrosis Factor-&agr;-Mediated Endothelial Apoptosis in the Development of Experimental Idiopathic Pneumonia Syndrome. Transplantation 2004, 78: 494-502. PMID: 15446306, DOI: 10.1097/01.tp.0000128839.13674.02.Peer-Reviewed Original ResearchConceptsExperimental Idiopathic Pneumonia SyndromeAllogeneic bone marrow transplantationIdiopathic pneumonia syndromeBone marrow transplantationTumor necrosis factorLung injuryTNF-alphaPneumonia syndromeNecrosis factorVascular endotheliumBronchoalveolar lavage fluid tumor necrosis factorDevelopment of IPSPulmonary vascular endothelial cell apoptosisAlloreactive donor T cellsInflammatory mediators TNF-alphaMinor histocompatibility antigenic differencesMurine BMT systemPulmonary vascular endotheliumDonor T cellsEC apoptosisVascular endothelial cell apoptosisEndothelial cell apoptosisHost diseaseLung histopathologyPulmonary histopathology
2003
LPAM (α4β7 integrin) is an important homing integrin on alloreactive T cells in the development of intestinal graft-versus-host disease
Petrovic A, Alpdogan O, Willis L, Eng J, Greenberg A, Kappel B, Liu C, Murphy G, Heller G, van den Brink M. LPAM (α4β7 integrin) is an important homing integrin on alloreactive T cells in the development of intestinal graft-versus-host disease. Blood 2003, 103: 1542-1547. PMID: 14563643, DOI: 10.1182/blood-2003-03-0957.Peer-Reviewed Original ResearchConceptsDonor T cellsT cellsMurine allogeneic bone marrow transplantation modelAllogeneic bone marrow transplantation modelAlloreactive donor T cellsGut-associated lymphoid tissueAdhesion moleculesMucosal addressin cell adhesion moleculeGVHD target organsMesenteric lymph nodesAlloreactive T cellsBone marrow transplantation modelMucosal lymphoid organsHigh endothelial venulesGVHD morbidityGVT activityIntestinal graftIntestinal GVHDLess graftLess GVHDHost diseaseLymph nodesDisease morbidityLymphoid organsLymphoid tissue