2007
Absence of donor T-cell–derived soluble TNF decreases graft-versus-host disease without impairing graft-versus-tumor activity
Borsotti C, Franklin A, Lu S, Kim T, Smith O, Suh D, King C, Chow A, Liu C, Alpdogan O, van den Brink M. Absence of donor T-cell–derived soluble TNF decreases graft-versus-host disease without impairing graft-versus-tumor activity. Blood 2007, 110: 783-786. PMID: 17395784, PMCID: PMC1924485, DOI: 10.1182/blood-2006-10-054510.Peer-Reviewed Original ResearchConceptsT cellsTNF-alpha converting enzymeGVT activityHost diseaseTumor activityAllogeneic bone marrow transplantationDonor T cellsBone marrow transplantationMurine BMT modelWild-type T cellsLess GVHDMarrow transplantationBMT modelNecrosis factorEndogenous TNFSoluble TNFGVHDConverting enzymeGraftTNFDiseaseRecipientsSoluble moleculesCellsMemTNF
2005
Absence of β7 integrin results in less graft-versus-host disease because of decreased homing of alloreactive T cells to intestine
Waldman E, Lu S, Hubbard V, Kochman A, Eng J, Terwey T, Muriglan S, Kim T, Heller G, Murphy G, Liu C, Alpdogan O, van den Brink M. Absence of β7 integrin results in less graft-versus-host disease because of decreased homing of alloreactive T cells to intestine. Blood 2005, 107: 1703-1711. PMID: 16291587, PMCID: PMC1895413, DOI: 10.1182/blood-2005-08-3445.Peer-Reviewed Original ResearchConceptsHematopoietic stem cell transplantationLess GVHD morbidityT cell infiltrationT cellsGVHD morbidityGVT activityHost diseaseDonor T-cell infiltrationDonor T cellsAlloreactive T cellsStem cell transplantationWild-type T cellsOverall significant decreaseIntestinal graftIntestinal GVHDLess graftBeta7 integrinCell transplantationCytokine productionAlpha4beta7 integrinIntact activationTumor experimentsMorbidityClinical potentialGraft