Donor leukocyte infusion from immunized donors increases tumor vaccine efficacy after allogeneic bone marrow transplantation.
Teshima T, Liu C, Lowler K, Dranoff G, Ferrara J. Donor leukocyte infusion from immunized donors increases tumor vaccine efficacy after allogeneic bone marrow transplantation. Cancer Research 2002, 62: 796-800. PMID: 11830535.Peer-Reviewed Original ResearchConceptsAllogeneic bone marrow transplantationBone marrow transplantationDonor leukocyte infusionImmunization of donorsLeukocyte infusionMarrow transplantationTumor vaccinesT cellsT cell-depleted allogeneic bone marrow transplantationTumor-specific T-cell responsesTumor vaccine efficacyDonor T cellsRecurrence of malignancyPotent antitumor immunityT cell responsesAnalysis of splenocytesT cell proliferationGranulocyte-macrophage colony-stimulating factorPotent T-cell proliferationNovel treatment strategiesColony-stimulating factorSpecific antitumor activityB16 melanoma cellsBeneficial graftHarmful graft