2009
T helper17 Cells Are Sufficient But Not Necessary to Induce Acute Graft-Versus-Host Disease
Iclozan C, Yu Y, Liu C, Liang Y, Yi T, Anasetti C, Yu X. T helper17 Cells Are Sufficient But Not Necessary to Induce Acute Graft-Versus-Host Disease. Transplantation And Cellular Therapy 2009, 16: 170-178. PMID: 19804837, PMCID: PMC3876952, DOI: 10.1016/j.bbmt.2009.09.023.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntibodies, MonoclonalBody WeightBone Marrow TransplantationCD3 ComplexCells, CulturedGraft vs Host DiseaseGraft vs Host ReactionInterferon-gammaInterleukin-17MiceMice, Inbred StrainsMice, TransgenicNuclear Receptor Subfamily 1, Group F, Member 3Severity of Illness IndexSurvival AnalysisT-Lymphocyte SubsetsT-Lymphocytes, Helper-InducerTh1 CellsTime FactorsTumor Necrosis Factor-alphaWhole Body ImagingConceptsHost diseaseBALB/c recipientsBone marrow transplantation settingAcute Graft-VersusT helper17 cellsGVHD target organsInduction of graftPathogenesis of GVHDCD4 T cellsGraft-VersusGVHD developmentC recipientsT helperTh17 cellsAllogeneic recipientsAutoimmune diseasesC57BL/6 miceSyngeneic recipientsTransplantation settingGVHDT cellsIFN-gammaTarget organsSuperior expansionDisease
2004
IL-13 - Predictor of or Protector from Acute Graft Versus Host Disease?.
Hildebrandt G, Olkiewicz K, Choi S, Corrion L, Liu C, McKenzie A, Cooke K. IL-13 - Predictor of or Protector from Acute Graft Versus Host Disease?. Blood 2004, 104: 3070. DOI: 10.1182/blood.v104.11.3070.3070.Peer-Reviewed Original ResearchBALB/c ILStem cell transplantationDonor T cellsIL-13T cellsC ILSyngeneic controlsTNFa levelsAllo-SCTHost diseaseTh2 cytokinesDonor cellsAcute Graft Versus Host DiseaseGraft Versus Host DiseaseAllogeneic stem cell transplantationTh1-type cytokine responseAltered cytokine milieuDay 100 survivalRecipients of ILTypical Th2 cytokineSeverity of GVHDVersus Host DiseaseIL-13 levelsIL-5 levelsPathogenesis of GVHD