2013
MicroRNA-34b inhibits pancreatic cancer metastasis through repressing Smad3.
Liu C, Cheng H, Shi S, Cui X, Yang J, Chen L, Cen P, Cai X, Lu Y, Wu C, Yao W, Qin Y, Liu L, Long J, Xu J, Li M, Yu X. MicroRNA-34b inhibits pancreatic cancer metastasis through repressing Smad3. 2013, 13: 467-78. PMID: 23305226, DOI: 10.2174/1566524011313040001.Peer-Reviewed Original ResearchConceptsMiR-34bTarget of miR-34bMicroRNA-34bTumor-suppressive microRNAMiR-34b expressionPancreatic cancer tissuesLuciferase assayProgression in vitroMicroRNAsCancer tissuesTumor-node-metastasisPancreatic cancerTumor metastasis suppressorTumor-node-metastasis (TNM) stageCancer progression in vitroMiRsLymph-node metastasisPancreatic cancer cellsPancreatic cancer metastasisER stress inducer thapsigargin
2011
Survivin Inhibition Is Critical for Bcl-2 Inhibitor-Induced Apoptosis in Hepatocellular Carcinoma Cells
Zhao X, Ogunwobi O, Liu C. Survivin Inhibition Is Critical for Bcl-2 Inhibitor-Induced Apoptosis in Hepatocellular Carcinoma Cells. PLOS ONE 2011, 6: e21980. PMID: 21829603, PMCID: PMC3148218, DOI: 10.1371/journal.pone.0021980.Peer-Reviewed Original ResearchConceptsBcl-2 inhibitorsCombination treatmentHCC cellsABT-263Survivin inhibitionHepatocellular carcinomaHuman liver cancer tissuesSingle treatmentFuture clinical trialsApoptotic effectsLiver cancer tissuesLiver cancer therapyERK activationHCC cell linesHepatocellular carcinoma cellsPreclinical dataClinical trialsTherapeutic effectLow doseNormal human hepatocytesCancer tissuesYM-155High dosesNovel Bcl-2 inhibitorABT-263-induced apoptosisEpigenetic regulation of homeobox genes in liver cancer
Liu H, Robertson K, Liu C. Epigenetic regulation of homeobox genes in liver cancer. The FASEB Journal 2011, 25: 794.12-794.12. DOI: 10.1096/fasebj.25.1_supplement.794.12.Peer-Reviewed Original ResearchHox genesEpigenetic regulationHomeobox genesAmino acid DNA-binding domainHox gene regulationDNA-binding domainHox gene familyHCC cell linesBp DNA sequenceCell linesGene familyGene regulationEpigenetic modificationsEpigenetic mechanismsIdentity of cellsTranscription factorsDNA sequencesTrichostatin A.Expression profilesCancer tissuesDifferential expressionGenesCell line experimentsNormal developmentHCC cancer tissuesDNA Methylation Suppresses Expression of the Urea Cycle Enzyme Carbamoyl Phosphate Synthetase 1 (CPS1) in Human Hepatocellular Carcinoma
Liu H, Dong H, Robertson K, Liu C. DNA Methylation Suppresses Expression of the Urea Cycle Enzyme Carbamoyl Phosphate Synthetase 1 (CPS1) in Human Hepatocellular Carcinoma. American Journal Of Pathology 2011, 178: 652-661. PMID: 21281797, PMCID: PMC3069978, DOI: 10.1016/j.ajpath.2010.10.023.Peer-Reviewed Original ResearchMeSH KeywordsCarbamoyl-Phosphate Synthase (Ammonia)Carcinoma, HepatocellularCell Line, TumorCpG IslandsDNA MethylationGene Expression Regulation, EnzymologicGene Expression Regulation, NeoplasticHepatocyte Nuclear Factor 3-betaHepatocytesHumansLiver NeoplasmsPromoter Regions, GeneticQuaternary Ammonium CompoundsRNA, MessengerUreaConceptsHCC cellsNoncancerous tissuesTumor tissueHepatocyte paraffin 1 antibodySurgical pathology practiceLiver cancer tissuesHuman HCC cellsCPS1 expressionHCC tumor tissuesLiver tumor tissuesHuman hepatocellular carcinomaHuman hepatocellular carcinoma cellsCultured human primary hepatocytesHuman primary hepatocytesHepatocellular carcinoma cellsHepatocellular carcinomaCPS1 geneRate-limiting enzymeLiver carcinogenesisCancer tissuesSynthetase 1Potential biomarkersCarbamoyl phosphate synthetase 1Pathology practiceCarcinoma cells