Breakdown of CTL Tolerance to Self HLA-B*2705 Induced by Exposure to Chlamydia trachomatis
Popov I, Dela Cruz CS, Barber BH, Chiu B, Inman RD. Breakdown of CTL Tolerance to Self HLA-B*2705 Induced by Exposure to Chlamydia trachomatis. The Journal Of Immunology 2002, 169: 4033-4038. PMID: 12244206, DOI: 10.4049/jimmunol.169.7.4033.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAnimals, Genetically ModifiedAutoantigensCells, CulturedChlamydia trachomatisCoculture TechniquesCytotoxicity, ImmunologicEpitopes, T-LymphocyteHLA-B AntigensHLA-B27 AntigenHumansL CellsLymphocyte ActivationLymphocyte Culture Test, MixedMiceRatsRats, Inbred LewSelf ToleranceT-Lymphocytes, CytotoxicTransfectionConceptsB27-transgenic ratsSuch immunized animalsGeneration of CTLMHC class IArthritogenic pathogensSelf-HLASeronegative arthritisCTL toleranceHLA-B27Arthritogenic peptidesCTL recognitionImmunized animalsRestriction elementsTransgenic ratsChlamydia trachomatisB27Disease pathogenesisSplenocytesClass IStrong associationCTLIntracellular bacteriaImmunizationChlamydiaRats