Charles Bruce, PhD
Associate Professor of NeuroscienceDownloadHi-Res Photo
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Neuroscience
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Neuroscience
333 Cedar Street
New Haven, CT 06520-8001
United States
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Associate Professor of Neuroscience
Appointments
Neuroscience
Associate Professor TenurePrimary
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- All Institutions
- Bruce Lab
- Neuroscience
- Yale Ventures
Education & Training
- PhD
- University of North Carolina (1976)
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Overview
Medical Research Interests
Cerebral Cortex; Neurobiology; Neurophysiology; Sensorimotor Cortex
ORCID
0000-0002-7481-5793- View Lab Website
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Research at a Glance
Publications Timeline
A big-picture view of Charles Bruce's research output by year.
Research Interests
Research topics Charles Bruce is interested in exploring.
45Publications
11,335Citations
Cerebral Cortex
Publications
2005
Neural circuitry of judgment and decision mechanisms
Opris I, Bruce CJ. Neural circuitry of judgment and decision mechanisms. Brain Research Reviews 2005, 48: 509-526. PMID: 15914255, DOI: 10.1016/j.brainresrev.2004.11.001.Peer-Reviewed Original ResearchCitationsMeSH Keywords and ConceptsConceptsDecision formationNeural circuitrySystems neuroscience approachHigher cognitive functionsOptimal behavioral responseNeuroscience approachResponse selectionReward expectationDecision mechanismCognitive functionNeural activitySensory inputBehavioral outputPrimate brainPrior experienceBehavioral responsesSubcortical areasDeliberation processCortical loopDecision circuitCircuitryJudgmentsDynamic interactionActivation thresholdSelection bias
2002
Eye Movements
Bruce C, Friedman H. Eye Movements. 2002, 269-297. DOI: 10.1016/b0-12-227210-2/00142-4.ChaptersCitations
2000
Supplementary Eye Field: Representation of Saccades and Relationship Between Neural Response Fields and Elicited Eye Movements
Russo G, Bruce C. Supplementary Eye Field: Representation of Saccades and Relationship Between Neural Response Fields and Elicited Eye Movements. Journal Of Neurophysiology 2000, 84: 2605-2621. PMID: 11068002, DOI: 10.1152/jn.2000.84.5.2605.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsSupplementary eye fieldElicited saccadesEye fieldElicited eye movementsSaccade directionVisual field coordinatesPeripheral target locationFrontal eye fieldNeural response fieldsVisual receptive fieldsVisuomovement neuronsCentral fixation pointPresaccadic activityOculomotor structuresContralateral saccadesOculomotor functionDirection of saccadesSuperior colliculusNeural dischargeSEF neuronsCentral fixationResponse fieldSaccade amplitudeSaccadesNeurons
1998
Deficits in Smooth-Pursuit Eye Movements After Muscimol Inactivation Within the Primate's Frontal Eye Field
Shi D, Friedman H, Bruce C. Deficits in Smooth-Pursuit Eye Movements After Muscimol Inactivation Within the Primate's Frontal Eye Field. Journal Of Neurophysiology 1998, 80: 458-464. PMID: 9658064, DOI: 10.1152/jn.1998.80.1.458.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsFrontal eye fieldSmooth eye movement regionPrimate frontal eye fieldMuscimol injectionsArcuate sulcusEye fieldGamma-aminobutyric acid agonistSP deficitsSmooth pursuit eye movementsMicroinjection of muscimolSmooth pursuit functionMuscimol inactivationEye movement directionInjected hemisphereReversible deficitsFEFsemPermanent deficitsNeuronal responsesPosterior bankAspiration lesionsLarge aspiration lesionsEye movementsMotion onsetNext dayMuscimol
1997
Suppression of Task-Related Saccades by Electrical Stimulation in the Primate's Frontal Eye Field
Burman D, Bruce C. Suppression of Task-Related Saccades by Electrical Stimulation in the Primate's Frontal Eye Field. Journal Of Neurophysiology 1997, 77: 2252-2267. PMID: 9163356, DOI: 10.1152/jn.1997.77.5.2252.Peer-Reviewed Original ResearchCitationsMeSH Keywords and ConceptsConceptsFrontal eye fieldPrimate frontal eye fieldSaccadic eye movementsElectrical stimulationEye fieldFEF sitesFoveal receptive fieldsSuppression of saccadesLow-intensity stimulationEye movementsCentral fixation targetMemory-guided saccadesAppropriate saccadeCortex anteriorFEF projectionsContraversive saccadesAnterior bankIntracortical microstimulationStimulation trialsPremotor cortexEvidence of suppressionReflexive saccadesMacaque monkeysSubcortical regionsFrontal lobe damage
1996
Neurons in the supplementary eye field of rhesus monkeys code visual targets and saccadic eye movements in an oculocentric coordinate system
Russo GS, Bruce CJ. Neurons in the supplementary eye field of rhesus monkeys code visual targets and saccadic eye movements in an oculocentric coordinate system. Journal Of Neurophysiology 1996, 76: 825-848. PMID: 8871203, DOI: 10.1152/jn.1996.76.2.825.Peer-Reviewed Original ResearchCitationsMeSH Keywords and ConceptsConceptsSupplementary eye fieldPresaccadic activitySaccadic eye movementsSEF neuronsOculocentric coordinate systemEye fieldEccentric orbital positionEye positionEye movementsInitial eye positionBeginning of saccadesMemory saccade taskFixation pointCentral fixation pointOculocentric coordinatesVisual cue presentationMacaque monkeysOculomotor rangeRhesus monkeysCraniocentric coordinatesNeuronsSaccade directionVisual targetsStimulus directionSaccades
1995
Topography of projections to posterior cortical areas from the macaque frontal eye fields
Stanton G, Bruce C, Goldberg M. Topography of projections to posterior cortical areas from the macaque frontal eye fields. The Journal Of Comparative Neurology 1995, 353: 291-305. PMID: 7745137, DOI: 10.1002/cne.903530210.Peer-Reviewed Original ResearchCitationsMeSH Keywords and ConceptsConceptsMedial superior temporal areaSuperior temporal polysensory areaVentral intraparietal areaLateral intraparietal areaMiddle temporal areaInferior temporal areasCortical areasTemporal-occipital areasTemporal areaMedial partArea MSTEye fieldIntraparietal areaArea PEVisual areasArea lateral intraparietal areaArea V2Macaque frontal eye fieldArea MTArea 23bParietal area 7aTemporal visual areaTopography of projectionsFrontal eye fieldSuperior temporal areaComparison of the smooth eye tracking disorder of schizophrenics with that of nonhuman primates with specific brain lesions
Macavoy M, Bruce C. Comparison of the smooth eye tracking disorder of schizophrenics with that of nonhuman primates with specific brain lesions. International Journal Of Neuroscience 1995, 80: 117-151. PMID: 7775044, DOI: 10.3109/00207459508986097.Peer-Reviewed Original ResearchCitationsMeSH Keywords and ConceptsConceptsEye tracking deficitsTracking deficitsLow gain pursuitFirst-degree relativesSpecific brain lesionsFrontal lobe theoryNeuroleptic medicationIntrusive saccadesBrain lesionsDegree relativesBrain areasFrontal lobeExperimental lesionsLesionsSchizophreniaSchizophrenicsDeficitsSaccadesFurther supportMedicationsReview
1994
Physiological correlate of fixation disengagement in the primate's frontal eye field
Dias E, Bruce C. Physiological correlate of fixation disengagement in the primate's frontal eye field. Journal Of Neurophysiology 1994, 72: 2532-2537. PMID: 7884478, DOI: 10.1152/jn.1994.72.5.2532.Peer-Reviewed Original ResearchCitationsMeSH Keywords and ConceptsConceptsFrontal eye fieldPresaccadic activityEye fieldPrimate frontal eye fieldMs. 3Short-latency saccadesGap taskDisengagement of fixationFixation disengagementVisuomovement cellsExpress saccadesFEF neuronsMean latencyFixation targetSaccade latencyRhesus monkeysSaccade taskSaccadic targetTrialsResponse fieldSaccadesSaccade targetCell fieldNeuronsFixation pointNeural responses related to smooth-pursuit eye movements and their correspondence with electrically elicited smooth eye movements in the primate frontal eye field
Gottlieb J, MacAvoy M, Bruce C. Neural responses related to smooth-pursuit eye movements and their correspondence with electrically elicited smooth eye movements in the primate frontal eye field. Journal Of Neurophysiology 1994, 72: 1634-1653. PMID: 7823092, DOI: 10.1152/jn.1994.72.4.1634.Peer-Reviewed Original ResearchCitationsMeSH Keywords and ConceptsConceptsSmooth eye movementsFrontal eye fieldPursuit neuronsEye movementsEye fieldPosterior bankPursuit directionPrimate frontal eye fieldMonkey frontal eye fieldSmooth pursuit eye movementsDirectional tuningBroad directional tuningSaccadic eye movementsSmooth pursuit trackingPursuit cellsMost neuronsIntracortical microstimulationPursuit velocityFEF neuronsFEF regionSmooth pursuitRhesus monkeysRegion involvementNeuron responsesNeurons
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Neuroscience
333 Cedar Street
New Haven, CT 06520-8001
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