Intense Expression of the B7-2 Antigen Presentation Coactivator Is an Unfavorable Prognostic Indicator for Differentiated Thyroid Carcinoma of Children and Adolescents
Shah R, Banks K, Patel A, Dogra S, Terrell R, Powers PA, Fenton C, Dinauer CA, Tuttle RM, Francis GL. Intense Expression of the B7-2 Antigen Presentation Coactivator Is an Unfavorable Prognostic Indicator for Differentiated Thyroid Carcinoma of Children and Adolescents. The Journal Of Clinical Endocrinology & Metabolism 2002, 87: 4391-4397. PMID: 12213904, DOI: 10.1210/jc.2002-011262.Peer-Reviewed Original ResearchConceptsB7-2 expressionThyroid carcinomaLymphocytic infiltrationB7-1B7-2Immune responseAdjacent thyroidImproved disease-free survivalDisease-free survivalTumor-associated lymphocytesDifferentiated thyroid carcinomaProbability of remissionUnfavorable prognostic indicatorB7-1 expressionFollicular thyroid carcinomaLong-term survivalHigh-power fieldBenign thyroid lesionsPrognostic indicatorThyroid diseaseAntigen presentationBenign tumorsMalignant tumorsCarcinomaThyroid lesionsMatrix metalloproteinase (MMP) expression by differentiated thyroid carcinoma of children and adolescents
Patel A, Straight A, Mann H, Duffy E, Fenton C, Dinauer C, Tuttle R, Francis G. Matrix metalloproteinase (MMP) expression by differentiated thyroid carcinoma of children and adolescents. Journal Of Endocrinological Investigation 2002, 25: 403-408. PMID: 12035934, DOI: 10.1007/bf03344028.Peer-Reviewed Original ResearchConceptsPapillary thyroid carcinomaFollicular thyroid carcinomaThyroid carcinomaTIMP-1MMP-1MMP-1 expressionMatrix metalloproteinasesMT1-MMPRecurrent papillary thyroid carcinomaTumor-associated inflammatory cellsPrevious pathological studiesTumor-associated lymphocytesDifferentiated thyroid carcinomaTIMP-1 expressionMatrix metalloproteinase expressionThyroid cancer cellsIntensity of stainingBenign thyroid lesionsMembrane type-1 matrix metalloproteinasesInflammatory cellsPathological studiesNormal thyroid cellsMalignant lesionsBenign lesionsMetalloproteinase expressionThyroid carcinomas that express telomerase follow a more aggressive clinical course in children and adolescents
Straight A, Patel A, Fenton C, Dinauer C, Tuttle R, Francis G. Thyroid carcinomas that express telomerase follow a more aggressive clinical course in children and adolescents. Journal Of Endocrinological Investigation 2002, 25: 302-308. PMID: 12030599, DOI: 10.1007/bf03344009.Peer-Reviewed Original ResearchConceptsFollicular thyroid carcinomaPapillary thyroid carcinomaThyroid carcinomaMalignant tumorsTelomerase expressionDisease-free survivalAggressive clinical courseChildhood thyroid cancerHigh recurrence riskYr of ageBenign thyroid lesionsLow telomerase expressionAutoimmune lesionsClinical courseDistant metastasisDirect invasionThyroid cancerBenign tumorsBlind examinerOriginal tumorBenign lesionsRecurrence riskTumorsThyroid lesionsCarcinoma