2024
Trends in use of intensive care during hospitalizations at the end‐of‐life among older adults with advanced cancer
Jain S, Long J, Rao V, Law A, Walkey A, Prsic E, Lindenauer P, Krumholz H, Gross C. Trends in use of intensive care during hospitalizations at the end‐of‐life among older adults with advanced cancer. Journal Of The American Geriatrics Society 2024 PMID: 39090970, DOI: 10.1111/jgs.19119.Peer-Reviewed Original ResearchEnd-of-life hospitalizationsLife-sustaining treatmentEnd-of-lifeIntensity of careIn-hospital deathOlder adultsIntensive care unitAdvanced cancerRisk-adjusted hospitalEvaluate trendsIncreased intensity of careIntensive care unit useSEER-Medicare dataIntensive care unit careMultinomial regression modelsYear of diagnosisIntensive careHospital categoryMedicare beneficiariesSEER-MedicareHospitalization ratesCareCancer characteristicsNoninvasive ventilationHospitalFunctional decline in older breast cancer survivors treated with and without chemotherapy and non-cancer controls: results from the Hurria Older PatiEnts (HOPE) prospective study
Sedrak M, Sun C, Bae M, Freedman R, Magnuson A, O’Connor T, Moy B, Wildes T, Klepin H, Chapman A, Tew W, Dotan E, Fenton M, Kim H, Katheria V, Muss H, Cohen H, Gross C, Ji J. Functional decline in older breast cancer survivors treated with and without chemotherapy and non-cancer controls: results from the Hurria Older PatiEnts (HOPE) prospective study. Journal Of Cancer Survivorship 2024, 18: 1131-1143. PMID: 38678525, PMCID: PMC11324395, DOI: 10.1007/s11764-024-01594-3.Peer-Reviewed Original ResearchEarly-stage breast cancerPF-10 scorePF-10Physical functionNon-cancer controlsFunctional declineBC controlOlder breast cancer survivorsRAND 36-Item Short FormBreast cancerCohort of older adultsOlder womenBreast cancer survivorsImprove health outcomesPhysical function subscalePhysical function declineAccelerated functional declineBreast Cancer StudyCancer survivorsFunction subscaleHealth outcomesGroup of womenOlder adultsControl groupShort form
2023
Trends in new and persistent opioid use in older adults with and without cancer
Baum L, KC M, Soulos P, Jeffery M, Ruddy K, Lerro C, Lee H, Graham D, Rivera D, Leapman M, Jairam V, Dinan M, Gross C, Park H. Trends in new and persistent opioid use in older adults with and without cancer. Journal Of The National Cancer Institute 2023, 116: 316-323. PMID: 37802882, DOI: 10.1093/jnci/djad206.Peer-Reviewed Original ResearchAdditional opioid useNew opioid useOpioid useNon-metastatic cancerPersistent opioid useRetrospective cohort studySolid tumor malignanciesClinical strataEligible patientsNaïve patientsOpioid prescribingMetastatic patientsSurgery patientsCohort studySEER-MedicareMetastatic cancerPatientsTumor malignancyCancerOlder adultsSurgeryRandom sampleAdditional useChemotherapyPrescribingNet Clinical Benefit as Measure of Treatment Benefit Among Older Adults With Advanced Incurable Non–Small Cell Lung Cancer—Reply
Voruganti T, Presley C, Gross C. Net Clinical Benefit as Measure of Treatment Benefit Among Older Adults With Advanced Incurable Non–Small Cell Lung Cancer—Reply. JAMA Oncology 2023, 9: 1154-1155. PMID: 37347467, DOI: 10.1001/jamaoncol.2023.1538.Peer-Reviewed Original ResearchFalls and hospitalization during chemotherapy in older women with early breast cancer.
Ji J, Sun C, Wildes T, Freedman R, Magnuson A, O'Connor T, Moy B, Klepin H, Chapman A, Tew W, Dotan E, Fenton M, Kim H, Bae M, Katheria V, Gross C, Muss H, Cohen H, Sedrak M. Falls and hospitalization during chemotherapy in older women with early breast cancer. Journal Of Clinical Oncology 2023, 41: 12035-12035. DOI: 10.1200/jco.2023.41.16_suppl.12035.Peer-Reviewed Original ResearchRisk of hospitalizationEarly breast cancerFall historyBreast cancerOlder adultsOlder womenStage II/III diseaseProspective multicenter studyMultivariable logistic regressionSelf-reported fall historyAdjuvant chemoCommon toxicitiesFebrile neutropeniaPrimary endpointPrimary prophylaxisGeriatric assessmentOlder patientsClinical factorsMedian ageAvoidable complicationsMulticenter studyClinical covariatesTreatment decisionsHospitalizationWomen's ageMetrics, baseline scores, and a tool to improve sponsor performance on clinical trial diversity: retrospective cross sectional study
Varma T, Mello M, Ross J, Gross C, Miller J. Metrics, baseline scores, and a tool to improve sponsor performance on clinical trial diversity: retrospective cross sectional study. BMJ Medicine 2023, 2: e000395. PMID: 36936269, PMCID: PMC9951369, DOI: 10.1136/bmjmed-2022-000395.Peer-Reviewed Original ResearchRetrospective cross-sectional studyCross-sectional studyPivotal trialsOlder adultsSectional studyNovel oncology therapeuticsUS cancer populationUS Cancer StatisticsUS patient populationAmerican Cancer SocietyPatient populationCancer populationOncology therapeuticsCancer SocietyCancer statisticsNovel cancer therapeuticsOncology trialsBaseline scoresPatientsUS FoodDrug AdministrationTrial dataStudy participantsTrialsEthics Committee
2017
Impact of hearing and visual impairment in older adults with cancer.
Soto Perez De Celis E, Sun C, Tew W, Mohile S, Gajra A, Klepin H, Owusu C, Gross C, Muss H, Lichtman S, Chapman A, Cohen H, Dale W, Kim H, Katheria V, Hurria A. Impact of hearing and visual impairment in older adults with cancer. Journal Of Clinical Oncology 2017, 35: 10036-10036. DOI: 10.1200/jco.2017.35.15_suppl.10036.Peer-Reviewed Original ResearchCognitive deficitsOlder adultsImpact of hearingVisual impairmentIADL dependencyImpaired hearingAnxietyDaily livingDeficitsInstrumental activitiesImpairmentDepressionHearingCross-sectional analysisAdultsChemotherapy toxicityOlder patientsProspective studyRisk factorsADL limitationsHigh riskSolid tumorsMultivariate analysisCancerRiskRisk factors for hospitalizations (HOS) among older adults with gastrointestinal (GI) cancers receiving chemotherapy.
Li D, Sun C, Levi A, Klepin H, Elias R, Mohile S, Tew W, Lim D, Chung V, Chao J, Owusu C, Muss H, Lichtman S, Gross C, Chapman A, Gajra A, Cohen H, Katheria V, Hurria A. Risk factors for hospitalizations (HOS) among older adults with gastrointestinal (GI) cancers receiving chemotherapy. Journal Of Clinical Oncology 2017, 35: e21523-e21523. DOI: 10.1200/jco.2017.35.15_suppl.e21523.Peer-Reviewed Original ResearchGI cancersRisk factorsCardiac comorbiditiesOlder adultsGeriatric assessmentOdds ratioLow serum albuminStage IV diseaseIncidence of hospitalizationRisk of hospitalizationAdults age 65Days post treatmentChemotherapy typePatient agePatient characteristicsProspective studyFemale sexGastrointestinal cancerChemotherapy treatmentUnivariate analysisLaboratory valuesHospitalizationChemotherapyMultivariate analysisPatients
2013
Measures of polypharmacy and chemotherapy toxicity in older adults with cancer.
Maggiore R, Feng T, Dale W, Gross C, Tew W, Mohile S, Owusu C, Klepin H, Lichtman S, Gajra A, McKoy J, Katheria V, Ramani R, Jayani R, Brown J, Hurria A. Measures of polypharmacy and chemotherapy toxicity in older adults with cancer. Journal Of Clinical Oncology 2013, 31: 9545-9545. DOI: 10.1200/jco.2013.31.15_suppl.9545.Peer-Reviewed Original ResearchPrevalence of polypharmacyPIM useChemotherapy toxicityOlder adultsGeriatric oncology populationAdverse clinical outcomesUnconditional logistic regressionAdverse drug eventsChi-square testInappropriate medicationsMedication useOncology populationPatient ageClinical outcomesDaily medicationInvasive cancerDrug eventsOutpatient populationGrade 3PolypharmacyReferent groupOlder personsSquare testLogistic regressionCancer
2012
Factors associated with life expectancy (LE) < 3 months (mo) among older adults receiving palliative chemotherapy (chemo).
Hurria A, Hardt M, Tew W, Mohile S, Owusu C, Gross C, Gajra A, Lichtman S, Katheria V, Ramani R, Zavala L, Klepin H. Factors associated with life expectancy (LE) < 3 months (mo) among older adults receiving palliative chemotherapy (chemo). Journal Of Clinical Oncology 2012, 30: 9034-9034. DOI: 10.1200/jco.2012.30.15_suppl.9034.Peer-Reviewed Original ResearchUnintentional weight lossPoor physical functionMultivariate logistic regressionAdvanced cancerLife expectancyPhysical functionWeight lossBivariate analysisLogistic regressionOlder adultsGeriatric assessment variablesMulti-site cohort studyLimited life expectancyPhysical function measuresFunctional status measuresOlder ptsPalliative chemoPalliative chemotherapyPalliative intentCohort studyPatient ageLow albuminFunctional statusOptimal treatmentRisk factorsAnemia and functional disability in older adults with cancer.
Owusu C, Tew W, Hardt M, Mohile S, Klepin H, Gross C, Gajra A, Lichtman S, Ramani R, Katheria V, Zavala L, Hurria A. Anemia and functional disability in older adults with cancer. Journal Of Clinical Oncology 2012, 30: 9109-9109. DOI: 10.1200/jco.2012.30.15_suppl.9109.Peer-Reviewed Original ResearchFunctional disabilityProspective studyOlder adultsMulti-center prospective studyUnintentional weight lossCorrection of anemiaRandomized-controlled trialPre-treatment variablesOlder ptsChemotherapy toxicityGeriatric assessmentPatient agePrimary outcomeMean HbFunctional statusInstrumental activitiesDaily livingAnemiaAdvanced stageMultivariate analysisAge 65Secondary analysisModifiable strategiesBivariate analysisLogistic regressionThe relationship among age, anxiety, and depression in older adults with cancer.
Weiss T, Nelson C, Tew W, Hardt M, Mohile S, Owusu C, Klepin H, Gross C, Gajra A, Lichtman S, Ramani R, Katheria V, Zavala L, Hurria A. The relationship among age, anxiety, and depression in older adults with cancer. Journal Of Clinical Oncology 2012, 30: 9123-9123. DOI: 10.1200/jco.2012.30.15_suppl.9123.Peer-Reviewed Original ResearchNumber of comorbiditiesOlder adultsMultivariable analysisPsychological sequelaeGeriatric assessment parametersProspective longitudinal studyDiagnosis of cancerSocial supportChemotherapy toxicityLonger hospitalTreatment regimensHospital AnxietyUnivariate analysisProstate cancerDepression ScaleMean depressionStage IIIStage IStage IVAverage ageAdvanced stageSignificant anxietySignificant depressionSecondary analysisStage II
2011
Polypharmacy, potentially inappropriate medications, and chemotherapy-related adverse events among older adults with cancer.
Maggiore R, Gross C, Hardt M, Tew W, Mohile S, Klepin H, Lichtman S, Owusu C, Gajra A, Ramani R, Katheria V, Brown J, Jayani R, Hurria A. Polypharmacy, potentially inappropriate medications, and chemotherapy-related adverse events among older adults with cancer. Journal Of Clinical Oncology 2011, 29: e19501-e19501. DOI: 10.1200/jco.2011.29.15_suppl.e19501.Peer-Reviewed Original Research
2010
Predicting chemotherapy toxicity in older adults with cancer: A prospective 500 patient multicenter study.
Hurria A, Togawa K, Mohile S, Owusu C, Klepin H, Gross C, Lichtman S, Katheria V, Klapper S, Tew W. Predicting chemotherapy toxicity in older adults with cancer: A prospective 500 patient multicenter study. Journal Of Clinical Oncology 2010, 28: 9001-9001. DOI: 10.1200/jco.2010.28.15_suppl.9001.Peer-Reviewed Original Research
2009
Geriatric assessment of older adults with cancer: Baseline data from a 500 patient multicenter study
Hurria A, Mohile S, Lichtman S, Owusu C, Klepin H, Gross C, Hansen K, Klapper S, Togawa K, Tew W. Geriatric assessment of older adults with cancer: Baseline data from a 500 patient multicenter study. Journal Of Clinical Oncology 2009, 27: 9546-9546. DOI: 10.1200/jco.2009.27.15_suppl.9546.Peer-Reviewed Original ResearchGeriatric assessmentOlder adultsBrief geriatric assessmentNew chemotherapy regimenStage IV diseaseComorbid medical conditionsMultivariate logistic regressionCommon tumor typesNon-white raceGross cognitive impairmentBlessed Orientation-MemoryChemotherapy regimenChemotherapy toxicityMetastatic diseaseOlder patientsPatient ageMulticenter studyFunctional statusProspective dataOncology practiceTreatment decisionsInstrumental activitiesMedical conditionsGYN cancersHigh school education