2017
Impact of hearing and visual impairment in older adults with cancer.
Soto Perez De Celis E, Sun C, Tew W, Mohile S, Gajra A, Klepin H, Owusu C, Gross C, Muss H, Lichtman S, Chapman A, Cohen H, Dale W, Kim H, Katheria V, Hurria A. Impact of hearing and visual impairment in older adults with cancer. Journal Of Clinical Oncology 2017, 35: 10036-10036. DOI: 10.1200/jco.2017.35.15_suppl.10036.Peer-Reviewed Original ResearchCognitive deficitsOlder adultsImpact of hearingVisual impairmentIADL dependencyImpaired hearingAnxietyDaily livingDeficitsInstrumental activitiesImpairmentDepressionHearingCross-sectional analysisAdultsChemotherapy toxicityOlder patientsProspective studyRisk factorsADL limitationsHigh riskSolid tumorsMultivariate analysisCancerRisk
2013
Measures of polypharmacy and chemotherapy toxicity in older adults with cancer.
Maggiore R, Feng T, Dale W, Gross C, Tew W, Mohile S, Owusu C, Klepin H, Lichtman S, Gajra A, McKoy J, Katheria V, Ramani R, Jayani R, Brown J, Hurria A. Measures of polypharmacy and chemotherapy toxicity in older adults with cancer. Journal Of Clinical Oncology 2013, 31: 9545-9545. DOI: 10.1200/jco.2013.31.15_suppl.9545.Peer-Reviewed Original ResearchPrevalence of polypharmacyPIM useChemotherapy toxicityOlder adultsGeriatric oncology populationAdverse clinical outcomesUnconditional logistic regressionAdverse drug eventsChi-square testInappropriate medicationsMedication useOncology populationPatient ageClinical outcomesDaily medicationInvasive cancerDrug eventsOutpatient populationGrade 3PolypharmacyReferent groupOlder personsSquare testLogistic regressionCancer
2012
Anemia and functional disability in older adults with cancer.
Owusu C, Tew W, Hardt M, Mohile S, Klepin H, Gross C, Gajra A, Lichtman S, Ramani R, Katheria V, Zavala L, Hurria A. Anemia and functional disability in older adults with cancer. Journal Of Clinical Oncology 2012, 30: 9109-9109. DOI: 10.1200/jco.2012.30.15_suppl.9109.Peer-Reviewed Original ResearchFunctional disabilityProspective studyOlder adultsMulti-center prospective studyUnintentional weight lossCorrection of anemiaRandomized-controlled trialPre-treatment variablesOlder ptsChemotherapy toxicityGeriatric assessmentPatient agePrimary outcomeMean HbFunctional statusInstrumental activitiesDaily livingAnemiaAdvanced stageMultivariate analysisAge 65Secondary analysisModifiable strategiesBivariate analysisLogistic regressionThe relationship among age, anxiety, and depression in older adults with cancer.
Weiss T, Nelson C, Tew W, Hardt M, Mohile S, Owusu C, Klepin H, Gross C, Gajra A, Lichtman S, Ramani R, Katheria V, Zavala L, Hurria A. The relationship among age, anxiety, and depression in older adults with cancer. Journal Of Clinical Oncology 2012, 30: 9123-9123. DOI: 10.1200/jco.2012.30.15_suppl.9123.Peer-Reviewed Original ResearchNumber of comorbiditiesOlder adultsMultivariable analysisPsychological sequelaeGeriatric assessment parametersProspective longitudinal studyDiagnosis of cancerSocial supportChemotherapy toxicityLonger hospitalTreatment regimensHospital AnxietyUnivariate analysisProstate cancerDepression ScaleMean depressionStage IIIStage IStage IVAverage ageAdvanced stageSignificant anxietySignificant depressionSecondary analysisStage IIPredictors of early discontinuation of chemotherapy (EDC) in patients (pts) age 65 or older with stage IV non-small cell lung cancer (NSCLC).
Gajra A, Tew W, Hardt M, Mohile S, Owusu C, Klepin H, Gross C, Lichtman S, Katheria V, Hurria A. Predictors of early discontinuation of chemotherapy (EDC) in patients (pts) age 65 or older with stage IV non-small cell lung cancer (NSCLC). Journal Of Clinical Oncology 2012, 30: e18133-e18133. DOI: 10.1200/jco.2012.30.15_suppl.e18133.Peer-Reviewed Original ResearchStage IV non-small cell lung cancerNon-small cell lung cancerPoor physical functionOlder ptsPhysical functionAge 65Multi-site prospective studyBivariate analysisGeriatric assessment variablesPatients age 65Cell lung cancerMultivariate logistic regressionLower mean HbPt ageChemotherapy toxicityEarly discontinuationAlbumin levelsMean HbProspective studyPoor outcomeHigher cancerLung cancerPhysical scoresSubset analysisDisease progression
2010
Predicting chemotherapy toxicity in older adults with cancer: A prospective 500 patient multicenter study.
Hurria A, Togawa K, Mohile S, Owusu C, Klepin H, Gross C, Lichtman S, Katheria V, Klapper S, Tew W. Predicting chemotherapy toxicity in older adults with cancer: A prospective 500 patient multicenter study. Journal Of Clinical Oncology 2010, 28: 9001-9001. DOI: 10.1200/jco.2010.28.15_suppl.9001.Peer-Reviewed Original Research
2009
Geriatric assessment of older adults with cancer: Baseline data from a 500 patient multicenter study
Hurria A, Mohile S, Lichtman S, Owusu C, Klepin H, Gross C, Hansen K, Klapper S, Togawa K, Tew W. Geriatric assessment of older adults with cancer: Baseline data from a 500 patient multicenter study. Journal Of Clinical Oncology 2009, 27: 9546-9546. DOI: 10.1200/jco.2009.27.15_suppl.9546.Peer-Reviewed Original ResearchGeriatric assessmentOlder adultsBrief geriatric assessmentNew chemotherapy regimenStage IV diseaseComorbid medical conditionsMultivariate logistic regressionCommon tumor typesNon-white raceGross cognitive impairmentBlessed Orientation-MemoryChemotherapy regimenChemotherapy toxicityMetastatic diseaseOlder patientsPatient ageMulticenter studyFunctional statusProspective dataOncology practiceTreatment decisionsInstrumental activitiesMedical conditionsGYN cancersHigh school education