2022
Assessment of personal inhalation and skin exposures to polymeric methylene diphenyl diisocyanate during polyurethane fabric coating
Harari H, Bello D, Woskie S, Redlich CA. Assessment of personal inhalation and skin exposures to polymeric methylene diphenyl diisocyanate during polyurethane fabric coating. Toxicology And Industrial Health 2022, 38: 622-635. PMID: 35694796, DOI: 10.1177/07482337221107243.Peer-Reviewed Original ResearchConceptsSkin exposurePersonal inhalationOccupational asthmaHypersensitivity pneumonitisContact dermatitisInitial sensitizationWork exposureArea air samplesInhalation exposureOccupational limitsLiquid chromatography-tandem mass spectrometryHealth effects studiesHealth effectsPersonal airborne samplesGeometric meanChromatography-tandem mass spectrometryExposure characterizationInhalationExposureFuture studiesGreater exposureAirborne levelsSubstantial variabilityProtective measuresGeometric standard deviation
2014
Official American Thoracic Society Technical Standards: Spirometry in the Occupational Setting
Redlich CA, Tarlo SM, Hankinson JL, Townsend MC, Eschenbacher WL, Von Essen SG, Sigsgaard T, Weissman DN. Official American Thoracic Society Technical Standards: Spirometry in the Occupational Setting. American Journal Of Respiratory And Critical Care Medicine 2014, 189: 983-993. PMID: 24735032, DOI: 10.1164/rccm.201402-0337st.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsLung functionChronic obstructive pulmonary diseaseObstructive pulmonary diseasePosture-related changesInterpretation of spirometryEMBASE 1980Pulmonary diseaseSpirometry testingLung diseaseMedline 1950SpirometryClinical informationInhalation exposureRepeat testingSystematic reviewHealth programsLongitudinal changesOccupational settingsPercentage declineSpirometry techniciansFEV1Appropriate reference valuesReference valuesWorker exposureDisease
2008
Comparison of Task-Based Exposure Metrics for an Epidemiologic Study of Isocyanate Inhalation Exposures Among Autobody Shop Workers
Woskie SR, Bello D, Gore RJ, Stowe MH, Eisen EA, Liu Y, Sparer JA, Redlich CA, Cullen MR. Comparison of Task-Based Exposure Metrics for an Epidemiologic Study of Isocyanate Inhalation Exposures Among Autobody Shop Workers. Journal Of Occupational And Environmental Hygiene 2008, 5: 588-598. PMID: 18615291, DOI: 10.1080/15459620802275429.Peer-Reviewed Original ResearchConceptsQuantitative exposure metricsOccupational exposure limitsEpidemiologic studiesExposure metricsRespirator useCross-week changesExposure-response analysisTime-weighted average exposureShop workersExposure assessmentPersonal daily exposureMagnitude of associationOccupational epidemiologic studiesWorkplace protection factorsQuantitative exposure assessmentTask-based exposure assessmentRespiratory functionInhalation exposureDaily exposureAverage exposureRisk estimatesExposure misclassificationQuantitative exposureSpearman correlationComparison of tasksLung/skin connections in occupational lung disease
Redlich C, Herrick C. Lung/skin connections in occupational lung disease. Current Opinion In Internal Medicine 2008, 7: 215-219. DOI: 10.1097/mci.0b013e328303e3cb.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsOccupational lung diseaseLung diseaseChronic beryllium diseaseSkin exposureIsocyanate asthmaBeryllium diseaseSite of sensitizationSubsequent inhalation challengeEnvironmental lung diseaseLimited clinical studiesImpair skin barrier functionSkin barrier functionAsthmatic responseInhalation challengeRespiratory tractHuman skin exposureClinical studiesInhalation exposureRecent studiesAnimal studiesAirborne exposureDiseaseBarrier functionPersonal protective clothingProtein allergensLung/skin connections in occupational lung disease
Redlich CA, Herrick CA. Lung/skin connections in occupational lung disease. Current Opinion In Allergy And Clinical Immunology 2008, 8: 115-119. PMID: 18317018, DOI: 10.1097/aci.0b013e3282f85a31.Peer-Reviewed Original ResearchConceptsOccupational lung diseaseLung diseaseChronic beryllium diseaseSkin exposureIsocyanate asthmaBeryllium diseaseSite of sensitizationSubsequent inhalation challengeEnvironmental lung diseaseLimited clinical studiesImpair skin barrier functionSkin barrier functionAsthmatic responseInhalation challengeRespiratory tractHuman skin exposureClinical studiesInhalation exposureRecent studiesAnimal studiesAirborne exposureDiseaseBarrier functionPersonal protective clothingProtein allergens
2006
Skin Exposure to Isocyanates: Reasons for Concern
Bello D, Herrick CA, Smith TJ, Woskie SR, Streicher RP, Cullen MR, Liu Y, Redlich CA. Skin Exposure to Isocyanates: Reasons for Concern. Environmental Health Perspectives 2006, 115: 328-335. PMID: 17431479, PMCID: PMC1849909, DOI: 10.1289/ehp.9557.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsSkin exposureIsocyanate asthmaSuch exposureAsthma-like responsesSubsequent inhalation challengeOccupational SafetyPersonal protective equipmentInhalation challengeOccupational asthmaSystemic sensitizationAsthmaInhalation exposureHealth AdministrationComputerized searchRespiratory exposureRelevant articlesProtective equipmentHuman literatureSkin absorptionSensitizationGoogle databasesNational InstituteLines of evidencePotential roleSufficient evidence