CD40L-specific mAb mediates its tolerogenic effects through engagement of FcgRIIB, not via depletion of activated T cells (141.17)
Lucas C, Fehr T, Haspot F, Sykes M. CD40L-specific mAb mediates its tolerogenic effects through engagement of FcgRIIB, not via depletion of activated T cells (141.17). The Journal Of Immunology 2009, 182: 141.17-141.17. DOI: 10.4049/jimmunol.182.supp.141.17.Peer-Reviewed Original ResearchCD8 T cellsBone marrow cellsAllogeneic bone marrow cellsT cellsCD8 cellsCD8 T cell toleranceLong-term mixed chimerismPeripheral CD8 T cellsTotal body irradiationDepletion of activated T cellsRecipient B cellsT cell toleranceFc-dependent functionsCD40L mAbDonor BMMixed chimerismDonor leukocytesBody irradiationKO recipientsB6 miceTolerogenic effectGraft acceptanceMarrow cellsFcgRIIbCD8