2024
Medial amygdalar tau is associated with mood symptoms in preclinical Alzheimer’s disease
Li J, Tun S, Ficek-Tani B, Xu W, Wang S, Horien C, Toyonaga T, Nuli S, Zeiss C, Powers A, Zhao Y, Mormino E, Fredericks C. Medial amygdalar tau is associated with mood symptoms in preclinical Alzheimer’s disease. Biological Psychiatry Cognitive Neuroscience And Neuroimaging 2024 PMID: 39059466, DOI: 10.1016/j.bpsc.2024.07.012.Peer-Reviewed Original ResearchAssociated with mood symptomsMood symptomsAmyloid-positive individualsMedial amygdalaSeed-based functional connectivity analysisAssociated with anxiety symptomsSelf-reported mood symptomsPost hoc correlation analysisAlzheimer's diseaseFunctional connectivity analysisPreclinical Alzheimer's diseaseTau bindingOrbitofrontal cortexTau depositionAmygdalar connectivityEmotional processingAnxiety symptomsRetrosplenial cortexBetween-group differencesAmygdalaFunctional connectivityLateral amygdalaConnectivity analysisDepression scoresNeuropsychiatric symptoms
2018
Early affective changes and increased connectivity in preclinical Alzheimer's disease
Fredericks CA, Sturm VE, Brown JA, Hua AY, Bilgel M, Wong DF, Resnick SM, Seeley WW. Early affective changes and increased connectivity in preclinical Alzheimer's disease. Alzheimer's & Dementia Diagnosis Assessment & Disease Monitoring 2018, 10: 471-479. PMID: 30302368, PMCID: PMC6174255, DOI: 10.1016/j.dadm.2018.06.002.Peer-Reviewed Original ResearchAffective changesEmotional reactivityPreclinical Alzheimer's diseaseInterpersonal warmthSocial-emotional processingEnhanced emotional reactivitySuperior temporal sulcusNormal older adultsSalience network connectivityHigher functional connectivityAmyloid-positive individualsHigh global connectivityMild Alzheimer's diseaseTemporal sulcusSalience networkSignificant stimuliRight insulaFunctional connectivityCognitive declineOlder adultsAffective symptomsAlzheimer's diseaseLongitudinal assessmentKey regionsWarmth