2004
A null mutation of Hhex results in abnormal cardiac development,defective vasculogenesis and elevated Vegfa levels
Hallaq H, Pinter E, Enciso J, McGrath J, Zeiss C, Brueckner M, Madri J, Jacobs HC, Wilson CM, Vasavada H, Jiang X, Bogue CW. A null mutation of Hhex results in abnormal cardiac development,defective vasculogenesis and elevated Vegfa levels. Development 2004, 131: 5197-5209. PMID: 15459110, DOI: 10.1242/dev.01393.Peer-Reviewed Original ResearchConceptsEpithelial-mesenchymal transformationVEGFA levelsVentricular septal defectVascular endothelial growth factorDefective vasculogenesisEndothelial growth factorEndocardial cushionsInhibitor of VEGFVascular developmentTract abnormalitiesSeptal defectSFlt-1Right ventricleNormal liverVentral foregut endodermNormal cardiovascular developmentReceptor 1Abnormal cardiac developmentGrowth factorNull mutationVentral foregutAberrant developmentCompact myocardiumAV explantsE8.5-9.0
2003
Feline Intraocular Tumors May Arise from Transformation of Lens Epithelium
Zeiss CJ, Johnson EM, Dubielzig RR. Feline Intraocular Tumors May Arise from Transformation of Lens Epithelium. Veterinary Pathology 2003, 40: 355-362. PMID: 12824506, DOI: 10.1354/vp.40-4-355.Peer-Reviewed Original ResearchConceptsSmooth muscle actinIntraocular sarcomaCollagen type IVMuscle actinGlial fibrillary acidic proteinMalignant intraocular neoplasmNerve growth factor receptorBasement membrane-type materialType IVFibrillary acidic proteinYears of ageExpression of vimentinEpithelial-mesenchymal phenotypeCell of originNeural cell adhesion moleculeExpression of desminGrowth factor receptorOcular traumaImmunohistochemical phenotypeIntraocular neoplasmPathophysiologic similaritiesUndifferentiated sarcomaEpithelial neoplasiaIntraocular tumorsMelan A