2009
CREB1/ATF1 Activation in Photoreceptor Degeneration and Protection
Beltran WA, Allore HG, Johnson E, Towle V, Tao W, Acland GM, Aguirre GD, Zeiss CJ. CREB1/ATF1 Activation in Photoreceptor Degeneration and Protection. Investigative Ophthalmology & Visual Science 2009, 50: 5355-5363. PMID: 19643965, PMCID: PMC3172238, DOI: 10.1167/iovs.09-3741.Peer-Reviewed Original ResearchMeSH KeywordsActivating Transcription Factor 1AgedAged, 80 and overAnimalsArrestinCell CountCiliary Neurotrophic FactorCyclic AMP Response Element-Binding ProteinDog DiseasesDogsFemaleGenotypeHumansImmunoblottingImmunoenzyme TechniquesMacular DegenerationMalePhosphorylationPhotoreceptor Cells, VertebrateRetinitis PigmentosaRhodopsinConceptsAge-related macular degenerationCiliary neurotrophic factorNormal canine retinaRcd1 dogsCanine retinaHuman retinaInnate protective responseNeuroprotective stimulusInner retinaNeurotrophic factorTranscription factor 1Macular degenerationRetinal protectionPhotoreceptor protectionP-CREB1Photoreceptor diseaseNormal dogsCanine modelPhotoreceptor degenerationRetinal degenerationProtective responseStrong immunolabelingCone photoreceptorsPhotoreceptor nucleiRetina
2004
Caspase-3 in Postnatal Retinal Development and Degeneration
Zeiss CJ, Neal J, Johnson EA. Caspase-3 in Postnatal Retinal Development and Degeneration. Investigative Ophthalmology & Visual Science 2004, 45: 964-970. PMID: 14985318, DOI: 10.1167/iovs.03-0439.Peer-Reviewed Original ResearchConceptsTerminal dUTP transferase nick end labelingPostnatal retinal developmentCaspase-3Photoreceptor degenerationRod deathMutant miceRetinal developmentInner nuclear layerDouble mutant miceNick end labelingLight microscopic levelRod photoreceptor developmentCell nuclear antigenNeonatal deathRetinal morphometryDysplastic lesionsRetinal dysplasiaNuclear layerPhotoreceptor protectionImmunohistochemical stainingRodent modelsFactor VIICaspase-3 activationNuclear antigenEnd labelingProliferation of Microglia, but not Photoreceptors, in the Outer Nuclear Layer of the rd-1 Mouse
Zeiss CJ, Johnson EA. Proliferation of Microglia, but not Photoreceptors, in the Outer Nuclear Layer of the rd-1 Mouse. Investigative Ophthalmology & Visual Science 2004, 45: 971-976. PMID: 14985319, DOI: 10.1167/iovs.03-0301.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsApoptosisBiomarkersCDC2-CDC28 KinasesCell Cycle ProteinsCell DivisionCyclin-Dependent Kinase 2Cyclin-Dependent Kinase 4Cyclin-Dependent KinasesDNA ReplicationImmunohistochemistryIn Situ Nick-End LabelingKi-67 AntigenMiceMice, Inbred C57BLMice, Mutant StrainsMicrogliaPhotoreceptor Cells, VertebrateProliferating Cell Nuclear AntigenProto-Oncogene ProteinsRetinal DegenerationConceptsOuter nuclear layerTerminal dUTP transferase nick end labelingNuclear layerCell cycle progressionMicroglial cellsPhotoreceptor deathCycle progressionProliferation of microgliaNick end labelingCell nuclear antigenControl miceNeurotrophic factorPeripheral gradientInner retinaNeuronal deathCell cycle proteinsPhotoreceptor lossRD-1Ki-67Postnatal dayPreexisting conditionsNeurodegenerative conditionsDouble immunolabelingBromodeoxyuridine uptakePhotoreceptor apoptosis