2007
Motor deficits and altered striatal gene expression in aphakia (ak) mice
Singh B, Wilson JH, Vasavada HH, Guo Z, Allore HG, Zeiss CJ. Motor deficits and altered striatal gene expression in aphakia (ak) mice. Brain Research 2007, 1185: 283-292. PMID: 17949697, PMCID: PMC3904435, DOI: 10.1016/j.brainres.2007.09.006.Peer-Reviewed Original ResearchConceptsSubstantia nigra pars compactaMonths of lifeAK miceWT miceParkinson's diseaseMotor performanceStriatal gene expressionDopaminergic denervationNigrostriatal dysfunctionStriatal denervationMotor deficitsPars compactaMotor abnormalitiesAphakia miceMice progressMotor functionStriatal transcriptomeDRD2 expressionPole testWT controlsSemi-quantitative RT-PCRAge groupsMiceRT-PCRTime points
2005
Neuroanatomical Phenotyping in the Mouse: The Dopaminergic System
Zeiss CJ. Neuroanatomical Phenotyping in the Mouse: The Dopaminergic System. Veterinary Pathology 2005, 42: 753-773. PMID: 16301571, DOI: 10.1354/vp.42-6-753.Peer-Reviewed Original ResearchConceptsCentral dopaminergic systemDopaminergic systemBasal nucleusMouse modelHuntington's diseaseTyrosine hydroxylase immunohistochemistryNonhuman primate brainAttention deficit hyperactivity disorderIndividual mouse modelsDeficit hyperactivity disorderSpecific anatomic regionsHydroxylase immunohistochemistryDopaminergic dysfunctionDopamine metabolismHuman neurologic disordersNeurologic disordersPrimate brainReceptor functionPaucity of informationVoluntary movementAnatomic regionsDiseaseMiceHyperactivity disorderMotor tests