2013
Cysteine-Mediated Redox Signaling: Chemistry, Biology, and Tools for Discovery
Paulsen CE, Carroll KS. Cysteine-Mediated Redox Signaling: Chemistry, Biology, and Tools for Discovery. Chemical Reviews 2013, 113: 4633-4679. PMID: 23514336, PMCID: PMC4303468, DOI: 10.1021/cr300163e.Peer-Reviewed Original Research
2011
Peroxide-dependent sulfenylation of the EGFR catalytic site enhances kinase activity
Paulsen CE, Truong TH, Garcia FJ, Homann A, Gupta V, Leonard SE, Carroll KS. Peroxide-dependent sulfenylation of the EGFR catalytic site enhances kinase activity. Nature Chemical Biology 2011, 8: 57-64. PMID: 22158416, PMCID: PMC3528018, DOI: 10.1038/nchembio.736.Peer-Reviewed Original Research
2009
Orchestrating Redox Signaling Networks through Regulatory Cysteine Switches
Paulsen CE, Carroll KS. Orchestrating Redox Signaling Networks through Regulatory Cysteine Switches. ACS Chemical Biology 2009, 5: 47-62. PMID: 19957967, PMCID: PMC4537063, DOI: 10.1021/cb900258z.Peer-Reviewed Original ResearchConceptsProtein functionReactive oxygen speciesIntracellular signal transductionCysteine switchRedox regulationSignal transductionCysteine oxidationCysteine residuesCurrent mechanistic insightsSecond messengerDiverse mechanismsMechanistic understandingMechanistic insightsOxygen speciesChemoselective oxidationNew therapeutic strategiesHydrogen peroxideRecent advancesOxidationTherapeutic strategiesTransductionSpeciesProteinMessengerResidues