Orchestrating Redox Signaling Networks through Regulatory Cysteine Switches
Paulsen CE, Carroll KS. Orchestrating Redox Signaling Networks through Regulatory Cysteine Switches. ACS Chemical Biology 2009, 5: 47-62. PMID: 19957967, PMCID: PMC4537063, DOI: 10.1021/cb900258z.Peer-Reviewed Original ResearchConceptsProtein functionReactive oxygen speciesIntracellular signal transductionCysteine switchRedox regulationSignal transductionCysteine oxidationCysteine residuesCurrent mechanistic insightsSecond messengerDiverse mechanismsMechanistic understandingMechanistic insightsOxygen speciesChemoselective oxidationNew therapeutic strategiesHydrogen peroxideRecent advancesOxidationTherapeutic strategiesTransductionSpeciesProteinMessengerResiduesChemical Dissection of an Essential Redox Switch in Yeast
Paulsen CE, Carroll KS. Chemical Dissection of an Essential Redox Switch in Yeast. Cell Chemical Biology 2009, 16: 217-225. PMID: 19230722, DOI: 10.1016/j.chembiol.2009.01.003.Peer-Reviewed Original ResearchConceptsSulfenic acidCell-permeable chemical probesSulfenic acid modificationCysteine sulfenic acid modificationTranscription factor Yap1Chemical probesCysteine oxidationRedox switchElectrostatic calculationsIntermolecular disulfide formationCharge distributionHydrogen peroxideAcid modificationNuclear accumulationIntermolecular disulfideConformational rearrangementsDisulfide formationCentral unresolved questionYAP1 activationYAP1GPX3Chemical dissectionCatalysisUnresolved questionsAcid