2008
Neuropsychological Near Normality and Brain Structure Abnormality in Schizophrenia
Wexler BE, Zhu H, Bell MD, Nicholls SS, Fulbright RK, Gore JC, Colibazzi T, Amat J, Bansal R, Peterson BS. Neuropsychological Near Normality and Brain Structure Abnormality in Schizophrenia. American Journal Of Psychiatry 2008, 166: 189-195. PMID: 18765481, PMCID: PMC4288572, DOI: 10.1176/appi.ajp.2008.08020258.Peer-Reviewed Original ResearchConceptsHealthy comparison subjectsComparison subjectsCognitive deficitsCalifornia Verbal Learning TestScores one standard deviationTests of attentionVerbal Learning TestContinuous Performance TestLarger third ventricle volumesMixed-model multivariate analysisSmaller gray matterWhite matterVentricle volumeSevere cognitive deficitsBrain structure abnormalitiesGray matterLearning TestLarger lateral ventricle volumesCognitive testsThird ventricle volumesLateral ventricle volumeWhite matter pathologySmaller white matterImpaired groupNeuropsychological testing
2006
Neuropsychological deficits in nonsmokers with schizophrenia: Effects of a nicotinic antagonist
Sacco KA, Termine A, Dudas MM, Seyal AA, Allen TM, Vessicchio JC, Wexler BE, George TP. Neuropsychological deficits in nonsmokers with schizophrenia: Effects of a nicotinic antagonist. Schizophrenia Research 2006, 85: 213-221. PMID: 16678390, DOI: 10.1016/j.schres.2006.03.025.Peer-Reviewed Original ResearchConceptsWisconsin Card Sorting TestContinuous Performance TestControl nonsmokersNeuropsychological performanceStroop Color-Word TestNeuropsychological deficitsNicotinic acetylcholine receptor systemAcetylcholine receptor systemPosition testVisuospatial working memoryCigarette smokingAntagonist mecamylamineNicotinic antagonistsNeuropsychological dysfunctionNAChR blockadeNonsmokersSchizophrenia diagnosisColor-Word TestMecamylamineReceptor systemNeuropsychological assessmentSchizophreniaCard Sorting TestCounterbalanced designTest week
2004
Neuropsychological deficits are associated with smoking cessation treatment failure in patients with schizophrenia
Dolan SL, Sacco KA, Termine A, Seyal AA, Dudas MM, Vessicchio JC, Wexler BE, George TP. Neuropsychological deficits are associated with smoking cessation treatment failure in patients with schizophrenia. Schizophrenia Research 2004, 70: 263-275. PMID: 15329302, DOI: 10.1016/j.schres.2004.01.006.Peer-Reviewed Original ResearchConceptsNon-psychiatric control smokersTreatment failureStroop Color-Word TestContinuous Performance TestNeuropsychological deficitsControl smokersWisconsin Card Sorting TestPlacebo-controlled trialAtypical antipsychotic treatmentCessation treatmentAntipsychotic treatmentCessation interventionsCigarette smokingDepressive symptomsPharmacological agentsColor-Word TestSmokingNeuropsychological assessmentNeuropsychological performanceCard Sorting TestVisuospatial Working Memory TaskGreater deficitsPreliminary dataSmokersPatients