2006
Neuropsychological deficits in nonsmokers with schizophrenia: Effects of a nicotinic antagonist
Sacco KA, Termine A, Dudas MM, Seyal AA, Allen TM, Vessicchio JC, Wexler BE, George TP. Neuropsychological deficits in nonsmokers with schizophrenia: Effects of a nicotinic antagonist. Schizophrenia Research 2006, 85: 213-221. PMID: 16678390, DOI: 10.1016/j.schres.2006.03.025.Peer-Reviewed Original ResearchConceptsWisconsin Card Sorting TestContinuous Performance TestControl nonsmokersNeuropsychological performanceStroop Color-Word TestNeuropsychological deficitsNicotinic acetylcholine receptor systemAcetylcholine receptor systemPosition testVisuospatial working memoryCigarette smokingAntagonist mecamylamineNicotinic antagonistsNeuropsychological dysfunctionNAChR blockadeNonsmokersSchizophrenia diagnosisColor-Word TestMecamylamineReceptor systemNeuropsychological assessmentSchizophreniaCard Sorting TestCounterbalanced designTest week
2004
Neuropsychological deficits are associated with smoking cessation treatment failure in patients with schizophrenia
Dolan SL, Sacco KA, Termine A, Seyal AA, Dudas MM, Vessicchio JC, Wexler BE, George TP. Neuropsychological deficits are associated with smoking cessation treatment failure in patients with schizophrenia. Schizophrenia Research 2004, 70: 263-275. PMID: 15329302, DOI: 10.1016/j.schres.2004.01.006.Peer-Reviewed Original ResearchConceptsNon-psychiatric control smokersTreatment failureStroop Color-Word TestContinuous Performance TestNeuropsychological deficitsControl smokersWisconsin Card Sorting TestPlacebo-controlled trialAtypical antipsychotic treatmentCessation treatmentAntipsychotic treatmentCessation interventionsCigarette smokingDepressive symptomsPharmacological agentsColor-Word TestSmokingNeuropsychological assessmentNeuropsychological performanceCard Sorting TestVisuospatial Working Memory TaskGreater deficitsPreliminary dataSmokersPatients
2001
Effects of Smoking Abstinence on Visuospatial Working Memory Function in Schizophrenia
George TP, Vessicchio JC, Termine A, Sahady DM, Head CA, Pepper WT, Kosten TR, Wexler BE. Effects of Smoking Abstinence on Visuospatial Working Memory Function in Schizophrenia. Neuropsychopharmacology 2001, 26: 75-85. PMID: 11751034, DOI: 10.1016/s0893-133x(01)00296-2.Peer-Reviewed Original ResearchConceptsVisuospatial working memorySmoking abstinenceStroop Color-Word TestAbstinence-induced changesWorking Memory FunctionColor-Word TestPlacebo-controlled smoking cessation trialFunction of genderWorking memoryCigarette smokingWord TestSmoking cessation trialCognitive functionCognitive deficitsMemory functionNicotine-dependent cigarette smokersNon-smoking controlsSignificant impairmentPathophysiology of schizophreniaDopamine functionCortical dopamine functionCessation trialSchizophrenic smokersDepressive symptomsAbstinence