2022
Returning to basic principles to develop more effective treatments for central nervous system disorders
Wexler BE. Returning to basic principles to develop more effective treatments for central nervous system disorders. Experimental Biology And Medicine 2022, 247: 856-867. PMID: 35172621, PMCID: PMC9158240, DOI: 10.1177/15353702221078291.Peer-Reviewed Original ResearchConceptsCentral nervous systemPositron emission tomographyNeuroplastic processesMagnetic stimulationCentral nervous system disordersFunctional magnetic resonance imaging (fMRI) imagingNervous system disordersMagnetic resonance imaging (MRI) imagingSystem-based initiativesCNS diseasesClinical trialsEffective treatmentSystem disordersSide effectsNervous systemNew treatmentsClinical disordersCandidate drugsEmission tomographyBrain functionPreclinical research
2012
Computerized cognitive remediation training for schizophrenia: An open label, multi-site, multinational methodology study
Murthy NV, Mahncke H, Wexler BE, Maruff P, Inamdar A, Zucchetto M, Lund J, Shabbir S, Shergill S, Keshavan M, Kapur S, Laruelle M, Alexander R. Computerized cognitive remediation training for schizophrenia: An open label, multi-site, multinational methodology study. Schizophrenia Research 2012, 139: 87-91. PMID: 22342330, DOI: 10.1016/j.schres.2012.01.042.Peer-Reviewed Original ResearchConceptsFunctional capacity outcome measuresCognitive Assessment InterviewBrain Fitness ProgramSignificant treatment effectOutcome measuresRegular antipsychotic medicationStable adult patientsNon-pharmacological methodsCognitive performanceTreatment effectsComputerized cognitive remediation trainingMultinational clinical trialsSingle-site studyTraining effectsCognitive remediation trainingOpen labelAdult patientsAntipsychotic medicationCAI scoreClinical trialsCognitive impairmentMulti-site studyExercise taskRemediation trainingNeuropsychological tasks
2004
Test–retest stability of neuropsychological testing and individual differences in variability in schizophrenia outpatients
Greig T, Nicholls SS, Wexler BE, Bell MD. Test–retest stability of neuropsychological testing and individual differences in variability in schizophrenia outpatients. Psychiatry Research 2004, 129: 241-247. PMID: 15661317, DOI: 10.1016/j.psychres.2004.09.006.Peer-Reviewed Original ResearchConceptsNeurocognitive functionImpact of treatmentTest-retest variabilityClinical trialsNeuropsychological testingStable outpatientsSchizoaffective disorderMeasures of psychopathologyTest-retest changesMost subjectsSchizophrenia outpatientsBaseline measuresNeuropsychological testsSchizophrenia researchTest-retest stabilityOutpatientsReliable instrumentSignificant changesTreatmentSubject variancePractice effectsSubjectsPatientsNeuropathology