2024
Do Transtibial Amputations Outperform Amputations of the Hind- and Midfoot Following Severe Limb Trauma?
Fram B, Bosse M, Odum S, Reider L, Gary J, Gordon W, Teague D, Alkhoury D, MacKenzie E, Seymour R, Karunakar M. Do Transtibial Amputations Outperform Amputations of the Hind- and Midfoot Following Severe Limb Trauma? Journal Of Bone And Joint Surgery 2024, 106: 776-781. PMID: 38512987, DOI: 10.2106/jbjs.23.00878.Peer-Reviewed Original ResearchConceptsShort Musculoskeletal Function AssessmentTranstibial amputationDistal amputationMidfoot amputationSevere lower-extremity injuriesLower-extremity injuriesLower-limb injuriesMusculoskeletal Function AssessmentPatient-reported outcomesMonths post-injuryBrief Pain IndexSevere limb traumaDescription of levels of evidenceTranstibial amputeesLevel of evidenceFoot traumaSMFA scoresAmputation revisionTherapeutic Level IIIYears of ageBother indexMidfootAmputation healingAverage SMFA scoreEmotional status
2020
Single-Incision 4-Compartment Fasciotomy of the Lower Leg: Safe, Effective, and Advantageous.
Chang G, Fram B, Krieg JC. Single-Incision 4-Compartment Fasciotomy of the Lower Leg: Safe, Effective, and Advantageous. Orthopedics 2020, 43: e225-e230. PMID: 32271928, DOI: 10.3928/01477447-20200404-03.Peer-Reviewed Original ResearchConceptsAcute compartment syndromeSingle-incision techniqueSkin closureInstances of malunionIntraoperative neurovascular injuryTibial fracture nonunionSingle-incision approachOptimal surgical approachMajority of surgeonsCompartment syndromeComplication rateWound breakdownSingle surgeonNeurovascular injuryRetrospective studySuperficial infectionSurgical approachFracture nonunionPrimary closureSecondary intentionSingle incisionVertical mattress suturesLower LegPatientsFasciotomy
2019
Clinical Outcomes and Complications of Peroneal Tendon Sheath Ultrasound-Guided Corticosteroid Injection
Fram BR, Rogero R, Fuchs D, Shakked RJ, Raikin SM, Pedowitz DI. Clinical Outcomes and Complications of Peroneal Tendon Sheath Ultrasound-Guided Corticosteroid Injection. Foot & Ankle International 2019, 40: 888-894. PMID: 31068007, DOI: 10.1177/1071100719847629.Peer-Reviewed Original ResearchConceptsCorticosteroid injectionBody mass indexMagnetic resonance imagingPain reliefPrior surgeryPeroneal tendonsClinical outcomesCompensation statusPeroneal tendinopathyNonsteroidal anti-inflammatory drugsWorkers' compensation statusDuration of symptomsPeroneal tendon tearsMedical record dataAnti-inflammatory drugsNumber of injectionsNonoperative modalitiesNerve irritationNonoperative treatmentUnderlying diagnosisNonoperative managementPatient ageCase seriesIntraoperative findingsMass index
2018
Surgical transposition for chronic instability of the extensor carpi ulnaris tendon
Fram B, Wall LB, Gelberman RH, Goldfarb CA. Surgical transposition for chronic instability of the extensor carpi ulnaris tendon. Journal Of Hand Surgery (European Volume) 2018, 43: 925-930. PMID: 29742949, DOI: 10.1177/1753193418773036.Peer-Reviewed Original ResearchConceptsExtensor carpi ulnaris tendonCarpi ulnaris tendonDorsal transpositionTendon instabilityPROMIS Pain Interference scoresPain interference scoresEffective surgical optionPre-injury levelUpper extremity scorePost-surgical patientsPatients' overall satisfactionAvailable outcome dataHigh-level athletesSurgical transpositionSymptom resolutionSurgical treatmentSurgical optionsExtremity scoreOutcome dataChronic instabilityInterference scoresPatientsLevel athletesTendonSurgery
2014
Outcomes After Involved-field Radiation Therapy (IFRT) With or Without Rituximab in Patients With Early-stage Low-grade Non-Hodgkin Lymphoma (NHL) Staged With CT and PET
Lukens JN, Nasta SD, Fram B, Glatstein E, Plastaras JP. Outcomes After Involved-field Radiation Therapy (IFRT) With or Without Rituximab in Patients With Early-stage Low-grade Non-Hodgkin Lymphoma (NHL) Staged With CT and PET. American Journal Of Clinical Oncology 2014, 37: 35-40. PMID: 22992623, DOI: 10.1097/coc.0b013e31826106c9.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAntibodies, Monoclonal, Murine-DerivedAntineoplastic AgentsConfounding Factors, EpidemiologicDisease-Free SurvivalFemaleFollow-Up StudiesHumansLymphoma, Non-HodgkinMaleMiddle AgedNeoplasm GradingNeoplasm StagingPositron-Emission TomographyRadiotherapy, Computer-AssistedRetrospective StudiesRituximabTomography, X-Ray ComputedTreatment OutcomeConceptsInvolved field radiation therapyProgression-free survivalNon-Hodgkin lymphomaLow-grade non-Hodgkin lymphomaPositron emission tomographyIndolent non-Hodgkin lymphomaComputed tomographyWeekly dosesRadiation therapyFavorable progression-free survivalImproved progression-free survivalOverall progression-free survivalReceipt of rituximabRituximab-treated patientsUse of rituximabPFS ratesMore patientsProspective studyHistorical controlsRetrospective analysisRituximabPatientsStage IIEmission tomographySignificant differences
2012
Maternally recruited Aurora C kinase is more stable than Aurora B to support mouse oocyte maturation and early development
Schindler K, Davydenko O, Fram B, Lampson MA, Schultz RM. Maternally recruited Aurora C kinase is more stable than Aurora B to support mouse oocyte maturation and early development. Proceedings Of The National Academy Of Sciences Of The United States Of America 2012, 109: e2215-e2222. PMID: 22778418, PMCID: PMC3421190, DOI: 10.1073/pnas.1120517109.Peer-Reviewed Original ResearchConceptsCell divisionEarly embryonic cell divisionsGerm cellsAbsence of transcriptionEmbryonic cell divisionAurora-C kinaseOne-cell stageAurora kinase activityMouse oocyte maturationAurora CPosttranscriptional regulationReporter proteinAurora BCytokinesis failureEmbryonic developmentEssential regulatorProtein stabilityKinase activityKinase isoformsFunctional analysisAURKCAurora kinasesC-kinaseThird isoformAURKB