2024
Do Transtibial Amputations Outperform Amputations of the Hind- and Midfoot Following Severe Limb Trauma?
Fram B, Bosse M, Odum S, Reider L, Gary J, Gordon W, Teague D, Alkhoury D, MacKenzie E, Seymour R, Karunakar M. Do Transtibial Amputations Outperform Amputations of the Hind- and Midfoot Following Severe Limb Trauma? Journal Of Bone And Joint Surgery 2024, 106: 776-781. PMID: 38512987, DOI: 10.2106/jbjs.23.00878.Peer-Reviewed Original ResearchConceptsShort Musculoskeletal Function AssessmentTranstibial amputationDistal amputationMidfoot amputationSevere lower-extremity injuriesLower-extremity injuriesLower-limb injuriesMusculoskeletal Function AssessmentPatient-reported outcomesMonths post-injuryBrief Pain IndexSevere limb traumaDescription of levels of evidenceTranstibial amputeesLevel of evidenceFoot traumaSMFA scoresAmputation revisionTherapeutic Level IIIYears of ageBother indexMidfootAmputation healingAverage SMFA scoreEmotional status
2022
Fracture-Associated Microbiome and Persistent Nonunion: Next-Generation Sequencing Reveals New Findings
Goswami K, Tipton C, Clarkson S, Chang G, Tan TL, Fram B, Chisari E, Sobol K, Natoli RM, Conway JD, Altman GT, Parvizi J, Krieg JC. Fracture-Associated Microbiome and Persistent Nonunion: Next-Generation Sequencing Reveals New Findings. Journal Of Orthopaedic Trauma 2022, 36: s40-s46. PMID: 35061650, DOI: 10.1097/bot.0000000000002305.Peer-Reviewed Original ResearchConceptsPersistent nonunionLong bone nonunionOpen surgical interventionProspective multicenter studySignificant risk factorsAcute fracturesDevastating complicationIntraoperative specimensMulticenter studySurgical interventionFracture nonunionNonunion diagnosisRisk factorsNGS detectionNonunionUseful adjunctFracture healingClinical specimensPatientsClinical implicationsLevel IIMore casesNGS diagnosticsControl casesBacterial profiles
2021
Short-Term Complications and Outcomes of the Cadence Total Ankle Arthroplasty
Fram B, Corr DO, Rogero RG, Pedowitz DI, Tsai J. Short-Term Complications and Outcomes of the Cadence Total Ankle Arthroplasty. Foot & Ankle International 2021, 43: 371-377. PMID: 34549617, DOI: 10.1177/10711007211043853.Peer-Reviewed Original ResearchConceptsTotal ankle arthroplastyAnkle arthroplastyVisual analog scale pain ratingsAnkle Ability Measure (FAAM) ActivitiesAverage coronal alignmentSF-12 MentalSF-12 PCSVAS pain scoresAmerican Orthopaedic FootPeri-implant osteolysisPhysical component summaryBody mass indexTotal ankle replacementCoronal plane alignmentTotal Ankle SystemGood postoperative ROMMean score changesFAAM-ADLFAAM-SportsEarly complicationsOrthopaedic FootPain scoresSports subscalePostoperative rangePostoperative ROMImmediate Weight-Bearing and Range of Motion After Internal Fixation of Selected Malleolar Fractures: A Retrospective Controlled Study
Fram BR, Rogero RG, Chang G, Krieg JC, Raikin SM. Immediate Weight-Bearing and Range of Motion After Internal Fixation of Selected Malleolar Fractures: A Retrospective Controlled Study. Journal Of Orthopaedic Trauma 2021, 35: 308-314. PMID: 33177430, DOI: 10.1097/bot.0000000000002003.Peer-Reviewed Original ResearchConceptsOpen reduction internal fixationLoss of reductionMalleolar fracturesRange of motionTrauma centerInternal fixationSyndesmosis fixationPosterior malleolusAnkle open reduction internal fixationPrimary open reduction internal fixationLevel 1 urban trauma centerRetrospective case-control studyLevel 1 trauma centerFuture prospective randomized studiesCharleston Comorbidity IndexProspective Randomized StudyImmediate weight bearingReduction internal fixationBody mass indexMalleolar ankle fracturesOrthopedic specialty hospitalTherapeutic Level IIIUrban trauma centerCase-control studyNonoperative complications
2020
Single-Incision 4-Compartment Fasciotomy of the Lower Leg: Safe, Effective, and Advantageous.
Chang G, Fram B, Krieg JC. Single-Incision 4-Compartment Fasciotomy of the Lower Leg: Safe, Effective, and Advantageous. Orthopedics 2020, 43: e225-e230. PMID: 32271928, DOI: 10.3928/01477447-20200404-03.Peer-Reviewed Original ResearchConceptsAcute compartment syndromeSingle-incision techniqueSkin closureInstances of malunionIntraoperative neurovascular injuryTibial fracture nonunionSingle-incision approachOptimal surgical approachMajority of surgeonsCompartment syndromeComplication rateWound breakdownSingle surgeonNeurovascular injuryRetrospective studySuperficial infectionSurgical approachFracture nonunionPrimary closureSecondary intentionSingle incisionVertical mattress suturesLower LegPatientsFasciotomy
2014
Outcomes After Involved-field Radiation Therapy (IFRT) With or Without Rituximab in Patients With Early-stage Low-grade Non-Hodgkin Lymphoma (NHL) Staged With CT and PET
Lukens JN, Nasta SD, Fram B, Glatstein E, Plastaras JP. Outcomes After Involved-field Radiation Therapy (IFRT) With or Without Rituximab in Patients With Early-stage Low-grade Non-Hodgkin Lymphoma (NHL) Staged With CT and PET. American Journal Of Clinical Oncology 2014, 37: 35-40. PMID: 22992623, DOI: 10.1097/coc.0b013e31826106c9.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAntibodies, Monoclonal, Murine-DerivedAntineoplastic AgentsConfounding Factors, EpidemiologicDisease-Free SurvivalFemaleFollow-Up StudiesHumansLymphoma, Non-HodgkinMaleMiddle AgedNeoplasm GradingNeoplasm StagingPositron-Emission TomographyRadiotherapy, Computer-AssistedRetrospective StudiesRituximabTomography, X-Ray ComputedTreatment OutcomeConceptsInvolved field radiation therapyProgression-free survivalNon-Hodgkin lymphomaLow-grade non-Hodgkin lymphomaPositron emission tomographyIndolent non-Hodgkin lymphomaComputed tomographyWeekly dosesRadiation therapyFavorable progression-free survivalImproved progression-free survivalOverall progression-free survivalReceipt of rituximabRituximab-treated patientsUse of rituximabPFS ratesMore patientsProspective studyHistorical controlsRetrospective analysisRituximabPatientsStage IIEmission tomographySignificant differences