2022
Fracture-Associated Microbiome and Persistent Nonunion: Next-Generation Sequencing Reveals New Findings
Goswami K, Tipton C, Clarkson S, Chang G, Tan TL, Fram B, Chisari E, Sobol K, Natoli RM, Conway JD, Altman GT, Parvizi J, Krieg JC. Fracture-Associated Microbiome and Persistent Nonunion: Next-Generation Sequencing Reveals New Findings. Journal Of Orthopaedic Trauma 2022, 36: s40-s46. PMID: 35061650, DOI: 10.1097/bot.0000000000002305.Peer-Reviewed Original ResearchConceptsPersistent nonunionLong bone nonunionOpen surgical interventionProspective multicenter studySignificant risk factorsAcute fracturesDevastating complicationIntraoperative specimensMulticenter studySurgical interventionFracture nonunionNonunion diagnosisRisk factorsNGS detectionNonunionUseful adjunctFracture healingClinical specimensPatientsClinical implicationsLevel IIMore casesNGS diagnosticsControl casesBacterial profiles
2020
Single-Incision 4-Compartment Fasciotomy of the Lower Leg: Safe, Effective, and Advantageous.
Chang G, Fram B, Krieg JC. Single-Incision 4-Compartment Fasciotomy of the Lower Leg: Safe, Effective, and Advantageous. Orthopedics 2020, 43: e225-e230. PMID: 32271928, DOI: 10.3928/01477447-20200404-03.Peer-Reviewed Original ResearchConceptsAcute compartment syndromeSingle-incision techniqueSkin closureInstances of malunionIntraoperative neurovascular injuryTibial fracture nonunionSingle-incision approachOptimal surgical approachMajority of surgeonsCompartment syndromeComplication rateWound breakdownSingle surgeonNeurovascular injuryRetrospective studySuperficial infectionSurgical approachFracture nonunionPrimary closureSecondary intentionSingle incisionVertical mattress suturesLower LegPatientsFasciotomyAn Adjunct Indicator for the Diagnosis of Fracture-Related Infections: Platelet Count to Mean Platelet Volume Ratio
Strony J, Paziuk T, Fram B, Plusch K, Chang G, Krieg J. An Adjunct Indicator for the Diagnosis of Fracture-Related Infections: Platelet Count to Mean Platelet Volume Ratio. Journal Of Bone And Joint Infection 2020, 5: 54-59. PMID: 32455095, PMCID: PMC7242407, DOI: 10.7150/jbji.44116.Peer-Reviewed Original ResearchErythrocyte sedimentation rateFracture-related infectionC-reactive proteinMean platelet volume ratioPlatelet volume ratioNegative predictive valueFracture nonunionRevision surgeryPreoperative erythrocyte sedimentation rateReceiver operator characteristic curve analysisCurve analysisOperator characteristic curve analysisOrthopaedic fracture careReliable screening testROC curve analysisCharacteristic curve analysisDiagnosis of fractureSignificant demographic differencesCommon complicationFracture careAcute phaseRetrospective reviewPreoperative settingPlatelet countIntraoperative cultures