2012
Utility of peripheral blood flow cytometry in differentiating low grade versus high grade myelodysplastic syndromes (MDS) and in the evaluation of cytopenias.
Rashidi HH, Xu X, Wang HY, Shafi NQ, Rameshkumar K, Messer K, Smith BR, Rose MG. Utility of peripheral blood flow cytometry in differentiating low grade versus high grade myelodysplastic syndromes (MDS) and in the evaluation of cytopenias. International Journal Of Clinical And Experimental Pathology 2012, 5: 224-30. PMID: 22558477, PMCID: PMC3341683.Peer-Reviewed Original ResearchConceptsHigh-grade myelodysplastic syndromeChronic myelomonocytic leukemiaPeripheral blood flow cytometryEvaluation of cytopeniasBlood flow cytometryMyelodysplastic syndromeFlow cytometryDifferential diagnosisHigh-risk myelodysplastic syndromeLow-grade myelodysplastic syndromesRisk myelodysplastic syndromesCMML patientsMyelomonocytic leukemiaDiagnostic utilityCytopeniasPatientsCytometrySyndromeLow gradeDiagnosisLeukemia
2008
DNA ploidy analysis as an adjunct for the detection of relapse in B-lineage acute lymphoblastic leukemia
Kenney B, Zieske A, Rinder H, Smith B. DNA ploidy analysis as an adjunct for the detection of relapse in B-lineage acute lymphoblastic leukemia. Leukemia & Lymphoma 2008, 49: 42-48. PMID: 18203010, DOI: 10.1080/10428190701760052.Peer-Reviewed Original ResearchConceptsAcute lymphoblastic leukemiaDetection of relapseDNA ploidy analysisLymphoblastic leukemiaPloidy analysisB-lineageB-lineage acute lymphoblastic leukemiaCytometric DNA ploidy analysisDiagnosis of relapseNormal precursor B cellsPrecursor B cellsOriginal immunophenotypeRelapsed diseaseUnique immunophenotypeLeukemic immunophenotypesImmunophenotypic detectionRelapseB cellsPatientsImmunophenotypeFlow immunophenotypingFlow cytometryAneuploid populationsDiagnosisLeukemia
1992
A γδ+ T-Cell Leukemia Bearing a Novel t(8;14)(q24;q11) Translocation Demonstrates Spontaneous In Vitro Natural Killer-Like Activity
Maziarz R, Arced R, Bernstein S, Frazier L, Smith B, Kasai M, Tantravahi R, Strominger J. A γδ+ T-Cell Leukemia Bearing a Novel t(8;14)(q24;q11) Translocation Demonstrates Spontaneous In Vitro Natural Killer-Like Activity. Blood 1992, 79: 1523-1531. DOI: 10.1182/blood.v79.6.1523.1523.Peer-Reviewed Original ResearchNatural killer-like activityT-cell leukemiaClinical conditionsNon-major histocompatibility complexPatient's clinical conditionGamma delta TCRTumor cell lysisFresh leukemic blastsDelta 1 gene segmentIntracellular calcium fluxGamma delta lineageT cell linesHuman T-cell leukemiaLeukemic blastsCytolytic activityDelta TCRLeukemia blastsC-myc proto-oncogene locusCalcium fluxCell surface analysisHistocompatibility complexDelta lineageLeukemiaLeukemia cellsProto-oncogene locusA gamma delta+ T-cell leukemia bearing a novel t(8;14)(q24;q11) translocation demonstrates spontaneous in vitro natural killer-like activity.
Maziarz R, Arceci R, Bernstein S, Frazier L, Smith B, Kasai M, Tantravahi R, Strominger J. A gamma delta+ T-cell leukemia bearing a novel t(8;14)(q24;q11) translocation demonstrates spontaneous in vitro natural killer-like activity. Blood 1992, 79: 1523-31. PMID: 1532137, DOI: 10.1182/blood.v79.6.1523.bloodjournal7961523.Peer-Reviewed Original ResearchConceptsNatural killer-like activityT-cell leukemiaClinical conditionsNon-major histocompatibility complexPatient's clinical conditionGamma delta TCRTumor cell lysisFresh leukemic blastsDelta 1 gene segmentIntracellular calcium fluxGamma delta lineageT cell linesHuman T-cell leukemiaLeukemic blastsCytolytic activityDelta TCRLeukemia blastsC-myc proto-oncogene locusCalcium fluxCell surface analysisHistocompatibility complexDelta lineageLeukemiaLeukemia cellsProto-oncogene locus
1985
Natural killer lymphocytes in hairy cell leukemia: presence of phenotypically identifiable cells with defective functional activity.
Smith BR, Rosenthal DS, Ault KA. Natural killer lymphocytes in hairy cell leukemia: presence of phenotypically identifiable cells with defective functional activity. Experimental Hematology 1985, 13: 189-93. PMID: 3884356.Peer-Reviewed Original ResearchConceptsHairy cell leukemiaNK cellsNatural killerFluorescence-activated cell sorterNK activityNK functionCell leukemiaFunctional deficiencyNormal numbersPhenotypic NK cellsMajority of patientsStandard 51Cr releaseSevere functional deficiencyDefective functional activityK562 targetsNK populationPatientsSurface markersK562 cell lineFunctional activityCell populationsCell sorterCell linesLeukemiaIdentifiable cells