2023
Review of the role of the endogenous opioid and melanocortin systems in the restless legs syndrome
Walters A, Li Y, Koo B, Ondo W, Weinstock L, Champion D, Afrin L, Karroum E, Bagai K, Spruyt K. Review of the role of the endogenous opioid and melanocortin systems in the restless legs syndrome. Brain 2023, 147: 26-38. PMID: 37633259, PMCID: PMC10796165, DOI: 10.1093/brain/awad283.Peer-Reviewed Original ResearchConceptsRestless legs syndromeMu-opioid receptorsRLS patientsEndogenous opioidsLegs syndromeOpioid receptorsSerum ironΒ-endorphinMelanocortin systemIdiopathic restless legs syndromeRLS-like symptomsPeriodic limb movementsLow serum ironWild-type miceSensory changesMelanocyte stimulating hormoneReceptor blockersSerum ferritinAutopsy studyStriatal dopamineAdrenocorticotropic hormoneStimulating hormoneDopaminergic systemMouse modelTherapeutic efficacy
2020
Hypothyroidism in restless legs syndrome
Ahmed N, Kandil M, Elfil M, Jamal A, Koo BB. Hypothyroidism in restless legs syndrome. Journal Of Sleep Research 2020, 30: e13091. PMID: 32483857, DOI: 10.1111/jsr.13091.Peer-Reviewed Original ResearchConceptsRestless legs syndromeLegs syndromeRLS severityHigh prevalenceInternational RLS Study Group Severity ScaleHypothyroid participantsHypothyroidism prevalenceRLS FoundationRLS pathophysiologyRLS sufferersRLS prevalenceHypothyroid subjectsThyroid diseaseHypothyroidismSeverity ScalePrevalenceLine registryStudy objectiveSyndromePotential research participantsBiological mechanismsSeverityParticipantsPersonsHyperthyroidism0795 The Relationship Between Restless Legs Syndrome and Hypothyroidism
Ahmed N, Kandil M, Elfil M, Jamal A, Koo B. 0795 The Relationship Between Restless Legs Syndrome and Hypothyroidism. Sleep 2020, 43: a302-a303. DOI: 10.1093/sleep/zsaa056.791.Peer-Reviewed Original ResearchRestless legs syndromeHypothyroidism prevalenceRLS pathophysiologyRLS prevalenceLegs syndromeRLS severityInternational RLS Study Group Severity ScaleHigher RLS prevalenceCause of hypothyroidismHypothyroid participantsRLS FoundationClinical research participantsHypothyroid subjectsPhysician diagnosisControl subjectsThyroid diseaseHypothyroidismSeverity ScalePrevalenceLine registryPathophysiologySyndromeBiological mechanismsSeverityAge
2019
Chapter 4 Treatment of Sleep-Related Movement and Circadian Rhythm Disorders, Hypersomnolence, and Parasomnias
Miner B, Jiwa N, Koo B. Chapter 4 Treatment of Sleep-Related Movement and Circadian Rhythm Disorders, Hypersomnolence, and Parasomnias. 2019, 77-95. DOI: 10.1016/b978-0-12-813014-8.00004-4.ChaptersSleep disordersPeriodic limb movement disorderRestless legs syndromeLimb movement disorderCircadian rhythm sleep disordersCircadian rhythm disordersPharmacologic optionsHypersomnolence disordersLegs syndromeMovement disordersRhythm disordersDisordersChapter 4 TreatmentBehavioral modificationParasomniasTreatmentPsychotherapeutic modalitiesDifferent psychotherapeutic modalitiesHypersomnolenceMedicationsSyndrome
2018
Suicidal thought and behavior in individuals with restless legs syndrome
Para KS, Chow CA, Nalamada K, Kakade VM, Chilakamarri P, Louis ED, Koo BB. Suicidal thought and behavior in individuals with restless legs syndrome. Sleep Medicine 2018, 54: 1-7. PMID: 30529070, DOI: 10.1016/j.sleep.2018.09.019.Peer-Reviewed Original ResearchConceptsRestless legs syndromeInternational RLS Study Group Severity ScaleLifetime suicidal ideationLifetime depression historySuicidal ideationDepression historyLegs syndromeControl participantsBrief Lifetime Depression ScaleCambridge-Hopkins RLS questionnairePotential demographic confoundersRisk of suicideStepwise logistic regressionRLS sufferersRLS questionnaireRLS diagnosisRLS severityDepression ScaleSuicidal Behaviors QuestionnaireLifetime depressionSeverity ScaleDemographic confoundersSuicidal thoughtsLogistic regressionDepressionRestless legs syndrome and periodic limb movements during sleep in the Multi-Ethnic Study of Atherosclerosis
Doan TT, Koo BB, Ogilvie RP, Redline S, Lutsey PL. Restless legs syndrome and periodic limb movements during sleep in the Multi-Ethnic Study of Atherosclerosis. Sleep 2018, 41: zsy106. PMID: 29860522, PMCID: PMC6093310, DOI: 10.1093/sleep/zsy106.Peer-Reviewed Original ResearchConceptsRestless legs syndromePrevalence of RLSConcurrent restless legs syndromePeriodic limb movementsMulti-Ethnic StudyLegs syndromeObesity statusOdds of RLSLimb movementsPrevalence of PLMSCommunity-based sampleRace/ethnicityRLS symptomsClinical criteriaAdjusted modelPLMSStudy participantsPrevalenceOlder individualsCross-sectional dataAtherosclerosisSexSyndromeWhite participantsSleep0661 Suicidal Behavior in Restless Legs Syndrome
Para K, Chow C, Kakade V, Nalamada K, Chilakamarri P, Louis E, KOO B. 0661 Suicidal Behavior in Restless Legs Syndrome. Sleep 2018, 41: a245-a245. DOI: 10.1093/sleep/zsy061.660.Peer-Reviewed Original ResearchRestless legs syndromeLifetime depression historyLifetime suicidal thoughtsControl subjectsSuicidal behaviorLegs syndromeDepression historyBrief Lifetime Depression ScaleInternational RLS Severity ScaleSuicidal thoughtsRLS severity scaleLifetime suicidal behaviorHigh suicide riskSuicide risk factorsOverall cohortRLS patientsRLS severityDopamine agonistsRisk factorsRLS subjectsSuicidal planningDepression ScaleSuicidal Behaviors QuestionnaireSeverity ScaleRLS cohort
2016
Periodic leg movements during sleep: phenotype, neurophysiology, and clinical significance
Ferri R, Koo BB, Picchietti DL, Fulda S. Periodic leg movements during sleep: phenotype, neurophysiology, and clinical significance. Sleep Medicine 2016, 31: 29-38. PMID: 28341521, DOI: 10.1016/j.sleep.2016.05.014.Peer-Reviewed Original ResearchConceptsRestless legs syndromePeriodic leg movementsLeg movementsLeg motor activityLegs syndromePathophysiological correlatesClinical correlatesObjective findingsClinical significanceClinical conditionsNeurophysiologic aspectsCurrent evidencePLMSMotor phenomenaMotor activityAge groupsTypical phenotypeSleepRecent findingsCurrent knowledgeFurther researchCorrelatesFindingsPhenotypeScoringRestless Legs Syndrome: Current Concepts about Disease Pathophysiology
Koo B, Bagai K, Walters A. Restless Legs Syndrome: Current Concepts about Disease Pathophysiology. Tremor And Other Hyperkinetic Movements 2016, 6: 401. DOI: 10.5334/tohm.322.Peer-Reviewed Original ResearchRestless legs syndromeBrain areasLegs syndromeSerotonergic systemCingulate cortexIron deficiencyStructural brain abnormalitiesPost-central gyrusWidespread brain areasSensory brain areasEnglish language papersRLS patientsSensorimotor disorderBrain abnormalitiesAnatomic locationDisease pathophysiologySecondary responseBrain regionsPathophysiologyConsistent findingLanguage papersCurrent conceptsOpioidsGlutamatergicDopaminergicRestless Legs Syndrome: Current Concepts about Disease Pathophysiology
Koo BB, Bagai K, Walters AS. Restless Legs Syndrome: Current Concepts about Disease Pathophysiology. Tremor And Other Hyperkinetic Movements 2016, 6: 401. PMID: 27536462, PMCID: PMC4961894, DOI: 10.7916/d83j3d2g.Peer-Reviewed Original ResearchRestless legs syndromeBrain areasLegs syndromeSerotonergic systemCingulate cortexIron deficiencyStructural brain abnormalitiesPost-central gyrusWidespread brain areasSensory brain areasEnglish language papersRLS patientsSensorimotor disorderBrain abnormalitiesAnatomic locationDisease pathophysiologySecondary responseBrain regionsPathophysiologyConsistent findingLanguage papersCurrent conceptsOpioidsGlutamatergicDopaminergicRestless Legs Syndrome and Depression: Effect Mediation by Disturbed Sleep and Periodic Limb Movements
Koo BB, Blackwell T, Lee HB, Stone KL, Louis ED, Redline S, Group O. Restless Legs Syndrome and Depression: Effect Mediation by Disturbed Sleep and Periodic Limb Movements. American Journal Of Geriatric Psychiatry 2016, 24: 1105-1116. PMID: 27526989, PMCID: PMC5241001, DOI: 10.1016/j.jagp.2016.04.003.Peer-Reviewed Original ResearchConceptsSevere restless legs syndromeRestless legs syndromePeriodic limb movementsDepressive symptomsLegs syndromeSleep disturbancesMild restless legs syndromeFurther adjustmentAssociation of RLSLimb movementsCardiovascular risk factorsApnea-hypopnea indexBody mass indexPotential mediatorsCross-sectional analysisEffect sizeDopaminergic medicationMass indexOsteoporotic fracturesPLMS indexDisturbed sleepRisk factorsGDS scoresPhysical activitySleep efficiency
2015
Restless Legs Syndrome: Would You Like That with Movements or Without?
Koo B. Restless Legs Syndrome: Would You Like That with Movements or Without? Tremor And Other Hyperkinetic Movements 2015, 5: 316. DOI: 10.5334/tohm.280.Peer-Reviewed Original ResearchRestless legs syndromeDiagnosis of RLSRLS diagnosisPeriodic limb movementsSupplementary diagnostic criterionRLS sufferersLegs syndromeSubjective symptomsSleep disturbancesDiagnostic criteriaMotor phenomenaProper diagnosisPatients' descriptionsSensorimotor conditionsPLMSDiagnosisLimb movementsInvestigational levelsPathophysiologySyndromeSymptomsEpidemiologySleepPharmacologyQuality measures for the care of adult patients with restless legs syndrome.
Trotti LM, Goldstein CA, Harrod CG, Koo BB, Sharon D, Zak R, Chervin RD. Quality measures for the care of adult patients with restless legs syndrome. Journal Of Clinical Sleep Medicine 2015, 11: 293-310. PMID: 25700882, PMCID: PMC4346652, DOI: 10.5664/jcsm.4550.Peer-Reviewed Original ResearchConceptsRestless legs syndromeAccuracy of diagnosisAdult patientsLegs syndromeTreatment complicationsSymptom severityCare of patientsCommon sleep disorderEvidence-based treatmentsPotential side effectsQuality measure developmentRLS managementIron storesSleep disordersControl disordersDiagnostic criteriaSide effectsBetter outcomesRoutine assessmentAmerican AcademySleep medicinePatientsOutcomesSeverityComplications
2008
α‐Melanocyte stimulating hormone and adrenocorticotropic hormone: An alternative approach when thinking about restless legs syndrome?
Koo BB, Feng P, Dostal J, Strohl KP. α‐Melanocyte stimulating hormone and adrenocorticotropic hormone: An alternative approach when thinking about restless legs syndrome? Movement Disorders 2008, 23: 1234-1242. PMID: 18464280, PMCID: PMC7350876, DOI: 10.1002/mds.22035.Peer-Reviewed Original ResearchConceptsSlow-wave sleep IIRestless legs syndromeAdrenocorticotropic hormoneAlpha-MSHParadoxical sleepLegs syndromeQuiet wakePathogenesis of RLSAlpha-melanocyte stimulating hormoneActive wakeMeasurement of sleepIntracerebral cannulaeIntracerebroventricular administrationSleep fragmentationNormal salineSleep latencyStimulating hormoneSleep architectureFragmented sleepOwn controlMotor activityRatsSleepLimb movementsHormone