What defines a clinically meaningful outcome in the treatment of substance use disorders: reductions in direct consequences of drug use or improvement in overall functioning?
Kiluk BD, Fitzmaurice GM, Strain EC, Weiss RD. What defines a clinically meaningful outcome in the treatment of substance use disorders: reductions in direct consequences of drug use or improvement in overall functioning? Addiction 2018, 114: 9-15. PMID: 29900624, PMCID: PMC6289694, DOI: 10.1111/add.14289.Peer-Reviewed Original ResearchConceptsSubstance use disordersDrug useUse disordersMost substance use disordersTreatment Efficacy TrialMeaningful outcomesOverall functioningException of alcoholAlcohol-related consequencesAspects of functioningPharmacotherapy trialsEfficacy trialsHealth consequencesIndividual functioningTrialsLong-term functioningWeak associationDisordersCurrent standardFunctioningUse trialOutcomesAssociationAbstinence