Molecular and cellular reorganization of neural circuits in the human lineage
Sousa AMM, Zhu Y, Raghanti MA, Kitchen RR, Onorati M, Tebbenkamp ATN, Stutz B, Meyer KA, Li M, Kawasawa YI, Liu F, Perez RG, Mele M, Carvalho T, Skarica M, Gulden FO, Pletikos M, Shibata A, Stephenson AR, Edler MK, Ely JJ, Elsworth JD, Horvath TL, Hof PR, Hyde TM, Kleinman JE, Weinberger DR, Reimers M, Lifton RP, Mane SM, Noonan JP, State MW, Lein ES, Knowles JA, Marques-Bonet T, Sherwood CC, Gerstein MB, Sestan N. Molecular and cellular reorganization of neural circuits in the human lineage. Science 2017, 358: 1027-1032. PMID: 29170230, PMCID: PMC5776074, DOI: 10.1126/science.aan3456.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsGene Expression ProfilingHumansInterneuronsMacacaNeocortexNeural PathwaysPan troglodytesPhylogenySpecies SpecificityTranscriptomeConceptsSingle-cell transcriptomic dataDistinct functional categoriesDistinct cell typesBiosynthesis genesTranscriptome sequencingHuman lineageTranscriptomic dataFunctional categoriesCellular reorganizationExpression differencesPhylogenetic reorganizationFunctional analysisCell typesGenesCellular featuresCellular differencesHuman specificityNeural circuitsLineagesMultiple levelsReorganizationSequencingHumansChimpanzeesAdult humans