2017
Macrolides selectively inhibit mutant KCNJ5 potassium channels that cause aldosterone-producing adenoma
Scholl UI, Abriola L, Zhang C, Reimer EN, Plummer M, Kazmierczak BI, Zhang J, Hoyer D, Merkel JS, Wang W, Lifton RP. Macrolides selectively inhibit mutant KCNJ5 potassium channels that cause aldosterone-producing adenoma. Journal Of Clinical Investigation 2017, 127: 2739-2750. PMID: 28604387, PMCID: PMC5490757, DOI: 10.1172/jci91733.Peer-Reviewed Original ResearchConceptsAldosterone-producing adenomaAldosterone productionAdrenocortical cancer cell lineKCNJ5 potassium channelPotassium channel KCNJ5Motilin receptor agonistSteroid hormone aldosteroneMillions of casesAPA diagnosisCancer cell linesSevere hypertensionAdrenal glandReceptor agonistBenign tumorsHormone aldosteroneCalcium influxInvasive proceduresKCNJ5 mutationsAdrenocortical cellsNoninvasive diagnosisPotassium channelsMembrane depolarizationDiagnosisCell proliferationCell lines
1988
Neuromodulator‐Mediated Phosphorylation of Specific Proteins in a Neurotumor Hybrid Cell Line (NCB‐20)
Berry‐Kravis E, Kazmierczak B, Derechin V, Dawson G. Neuromodulator‐Mediated Phosphorylation of Specific Proteins in a Neurotumor Hybrid Cell Line (NCB‐20). Journal Of Neurochemistry 1988, 50: 1287-1296. PMID: 2450174, DOI: 10.1111/j.1471-4159.1988.tb10606.x.Peer-Reviewed Original ResearchMeSH Keywords1-Methyl-3-isobutylxanthine2-ChloroadenosineAdenosineAlprostadilAnimalsBrainCalcimycinColforsinCricetinaeCyclic AMPElectrophoresis, Polyacrylamide GelEmbryo, MammalianEnkephalin, LeucineEnkephalin, Leucine-2-AlanineHybrid CellsImmunoassayMiceNerve Tissue ProteinsNeuroblastomaNeurotransmitter AgentsPhosphoproteinsPhosphorylationProtein KinasesSerotoninTumor Cells, CulturedTyrosine 3-MonooxygenaseConceptsCyclic AMP-dependent protein kinaseAMP-dependent protein kinaseCalcium/phospholipid-dependent protein kinasePhospholipid-dependent protein kinaseProtein kinaseHybrid cell linesCalcium/phospholipid-dependent kinaseCalcium/calmodulin-dependent protein kinaseCalmodulin-dependent protein kinasePC12 cellsStimulation of phosphorylationPhospholipid-dependent kinaseCell linesDifferentiated PC12 cellsMajor synaptic proteinsUnique proteinsSpecific proteinsMajor proteinsKinasePhosphorylation