2019
Radiation therapy treatment facility and overall survival in the adjuvant setting for locally advanced head and neck squamous cell carcinoma
Lee NCJ, Kelly JR, An Y, Park HS, Judson BL, Burtness BA, Husain ZA. Radiation therapy treatment facility and overall survival in the adjuvant setting for locally advanced head and neck squamous cell carcinoma. Cancer 2019, 125: 2018-2026. PMID: 30748002, PMCID: PMC6541535, DOI: 10.1002/cncr.32001.Peer-Reviewed Original ResearchConceptsHigh-volume surgical facilitiesPostoperative radiation therapyNeck squamous cell carcinomaSquamous cell carcinomaOverall survivalSurvival benefitCell carcinomaSurgical facilitiesPropensity score-matched cohortAnnual case volumeDefinitive surgeryAdvanced headOS improvementImproved outcomesRadiation therapyCase volumeOral cavityPatientsReduced hazardMultivariate analysisSurgeryInvasive HNSCCCarcinomaSurvivalTreatment
2010
Increased Recurrences Using Intensity-Modulated Radiation Therapy in the Postoperative Setting
Turaka A, Li T, Sharma NK, Li L, Nicolaou N, Mehra R, Burtness B, Cohen RB, Lango MN, Horwitz EM, Ridge JA, Feigenberg SJ. Increased Recurrences Using Intensity-Modulated Radiation Therapy in the Postoperative Setting. American Journal Of Clinical Oncology 2010, 33: 599-603. PMID: 21063195, DOI: 10.1097/coc.0b013e3181c4c3cc.Peer-Reviewed Original ResearchMeSH KeywordsAdultAge DistributionAgedAged, 80 and overCarcinoma, Squamous CellCohort StudiesFemaleHead and Neck NeoplasmsHumansIncidenceMaleMiddle AgedNeck DissectionNeoplasm Recurrence, LocalNeoplasm StagingPostoperative CarePostoperative PeriodPrognosisRadiotherapy DosageRadiotherapy, Intensity-ModulatedRetrospective StudiesRisk AssessmentSex DistributionSurvival AnalysisTreatment FailureConceptsPatterns of failurePostoperative therapyRadiation therapyLocal failureMarginal failureNeck cancerRegional failureRetrospective single-institution studyFox Chase Cancer CenterHigh-risk PTVLocoregional failure rateAddition of chemotherapySingle-institution studySquamous cell carcinomaIntensity-modulated radiation therapyPersistence of diseaseLow-risk PTVConcurrent cisplatinCurative intentDefinitive radiationDefinitive RTNodal recurrencePostoperative settingMedian ageNodal stage