2024
An algorithm for standardization of tumor Infiltrating lymphocyte evaluation in head and neck cancers
Xirou V, Moutafi M, Bai Y, Nwe Aung T, Burela S, Liu M, Kimple R, Shabbir Ahmed F, Schultz B, Flieder D, Connolly D, Psyrri A, Burtness B, Rimm D. An algorithm for standardization of tumor Infiltrating lymphocyte evaluation in head and neck cancers. Oral Oncology 2024, 152: 106750. PMID: 38547779, PMCID: PMC11060915, DOI: 10.1016/j.oraloncology.2024.106750.Peer-Reviewed Original ResearchConceptsTumor-infiltrating lymphocytesHead and neck cancerTILs evaluationHPV-positiveNeck cancerPrognostic valueHead and neck squamous cell cancer casesTIL variablesAssociated with favorable prognosisHPV-negative headHPV-negative populationHematoxylin-eosin-stained sectionsCox regression analysisPotential clinical implicationsInter-observer variabilityInfiltrating lymphocytesClinicopathological factorsFavorable prognosisValidation cohortTumor cellsCancer casesProspective settingQuPath softwareRetrospective collectionPredictive significance
2004
Improved method for the detection of cytokeratin 19-positive cells in the peripheral blood of breast cancer patients
Alvero AB, Burtness BA, Ercan AG, Sapi E. Improved method for the detection of cytokeratin 19-positive cells in the peripheral blood of breast cancer patients. Laboratory Investigation 2004, 84: 658-661. PMID: 15105816, DOI: 10.1038/labinvest.3700086.Peer-Reviewed Original ResearchConceptsBreast cancer patientsQuantitative real-time reverse transcription-polymerase chain reactionCancer patientsDisease-free survivalReal-time reverse transcription-polymerase chain reactionReverse transcription-polymerase chain reactionDetection of cytokeratinClinical parametersPeripheral bloodPolymerase chain reactionCytokeratin 19PatientsTumor cellsChain reactionImproved assayAssaysCellsTherapyCytokeratinBlood