Predictive Molecular Biomarkers for HPV-Associated Head and Neck Squamous Cell Carcinoma
Yarbrough W, Schrank T, Blumberg J, Patel S, Hackman T, Lumley C, Burtness B, Issaeva N. Predictive Molecular Biomarkers for HPV-Associated Head and Neck Squamous Cell Carcinoma. International Journal Of Radiation Oncology • Biology • Physics 2022, 112: e17-e18. DOI: 10.1016/j.ijrobp.2021.12.178.Peer-Reviewed Original ResearchNeck squamous cell carcinomaSquamous cell carcinomaNF-kB activityGene expression classifierCell carcinomaPatient outcomesPrognostic biomarkerNF-kBNF-kB pathway genesBetter recurrence-free survivalGoal of physiciansHPV-Associated HeadProgression-free survivalRecurrence-free survivalHigh cure ratesTCGA dataIndependent patient cohortsPredictive molecular biomarkersNF-kB target genesQuality of lifeExpression classifierHNSCC survivorsInduction chemotherapyOPSCC tumorsConcurrent chemoradiation