The role of cetuximab in the treatment of squamous cell cancer of the head and neck
Burtness B. The role of cetuximab in the treatment of squamous cell cancer of the head and neck. Expert Opinion On Biological Therapy 2005, 5: 1085-1093. PMID: 16050785, DOI: 10.1517/14712598.5.8.1085.Peer-Reviewed Original ResearchConceptsEpidermal growth factor receptorEpidermal growth factorGrowth factor receptorImportant clinical prognostic markerTyrosine kinase growth factor receptorsSignal transduction moleculesFactor receptorCell cycle progressionIntracellular tyrosine kinaseSmall molecular inhibitorsTyrosine kinase domainNormal human cellsGrowth factorKinase domainTransduction moleculesCycle progressionEGFR expression correlatesTyrosine kinaseEGFR moleculesHuman cellsMetastatic phenotypeConformational changesPrevents activationMolecular inhibitorsImportant therapeutic targetCetuximab: an epidermal growth factor receptor chemeric human-murine monoclonal antibody.
Harding J, Burtness B. Cetuximab: an epidermal growth factor receptor chemeric human-murine monoclonal antibody. Drugs Of Today 2005, 41: 107-27. PMID: 15821783, DOI: 10.1358/dot.2005.41.2.882662.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntibodies, MonoclonalAntibodies, Monoclonal, HumanizedAntibody SpecificityAntineoplastic AgentsApoptosisArea Under CurveCell ProliferationCetuximabChemotherapy, AdjuvantClinical Trials as TopicDrug Resistance, NeoplasmErbB ReceptorsHalf-LifeHumansNeoplasmsNeovascularization, PathologicRadiation ToleranceConceptsEpidermal growth factor receptorImportant clinical prognostic markerHydrophobic transmembrane regionCell cycle progressionIntracellular tyrosine kinaseLigand-binding domainNormal human cellsProtein phosphorylationTransmembrane regionCytoplasmic regionGene transcriptionGrowth factor receptorEndogenous ligandCycle progressionExtracellular domainTyrosine kinaseOverall downregulationHuman cellsConformational changesNew anticancer therapiesHuman tumor cell linesErbB familyTumor cell linesVariety of cancersFactor receptor