2017
Combination of WEE1 and AURKA inhibition in HPV negative head and neck squamous cell carcinoma.
Parameswaran J, Lee J, Sandoval-Schaefer T, Koo J, Burtness B. Combination of WEE1 and AURKA inhibition in HPV negative head and neck squamous cell carcinoma. Journal Of Clinical Oncology 2017, 35: e14105-e14105. DOI: 10.1200/jco.2017.35.15_suppl.e14105.Peer-Reviewed Original ResearchAurora kinase APhospho-histone H3Mitotic entryCell deathHNSCC cell linesMechanism of synergyDefective spindle assemblyConfocal microscopyAURKA inhibitorsCell linesChromatin organizationAURKA inhibitor MLN8237P-CDK1Spindle assemblyKinase AMitotic catastropheWestern blot analysisTumor growthFormation assaysAURKA expressionHPV-negative HNSCC cell linesCell viability assaysMouse xenograft modelPotential therapeutic targetAURKA inhibition
2013
Aurora kinases in head and neck cancer
Mehra R, Serebriiskii IG, Burtness B, Astsaturov I, Golemis EA. Aurora kinases in head and neck cancer. The Lancet Oncology 2013, 14: e425-e435. PMID: 23993387, PMCID: PMC4139969, DOI: 10.1016/s1470-2045(13)70128-1.Peer-Reviewed Original ResearchConceptsAurora kinase AAurora kinasesKinase AExpression inhibits cell growthSquamous cell carcinomaHigh-throughput datasetsSmall molecule inhibitorsInhibits cell growthAurora kinase inhibitorsGenomic instabilityHealthy cellsBiological functionsKinaseCell growthCancer cellsEarly phase trialsKinase inhibitorsOverexpressionCellsDrug combination trialsNeck cancerCombination trialsPhase trialsSmall studyCarcinoma