2023
The Association Between Obstructive Sleep Apnea and Abnormal 82Rubidium Cardiac PET Perfusion Myocardial Flow Reserve
Aneni E, Thorn S, Feher A, Hong Chen J, Sinusas A, Yaggi H, Miller E. The Association Between Obstructive Sleep Apnea and Abnormal 82Rubidium Cardiac PET Perfusion Myocardial Flow Reserve. JACC Cardiovascular Imaging 2023, 16: 856-858. PMID: 36881426, PMCID: PMC10718199, DOI: 10.1016/j.jcmg.2022.11.024.Peer-Reviewed Original Research
2022
PET Myocardial Blood Flow for Post-transplant Surveillance and Cardiac Allograft Vasculopathy in Heart Transplant Recipients
Feher A, Miller EJ. PET Myocardial Blood Flow for Post-transplant Surveillance and Cardiac Allograft Vasculopathy in Heart Transplant Recipients. Current Cardiology Reports 2022, 24: 1865-1871. PMID: 36279035, DOI: 10.1007/s11886-022-01804-3.Peer-Reviewed Original ResearchMeSH KeywordsAllograftsCoronary AngiographyCoronary Artery DiseaseHeart TransplantationHumansMyocardial Perfusion ImagingPositron-Emission TomographyConceptsHeart transplant recipientsAllograft vasculopathyTransplant recipientsPositron emission tomography myocardial perfusionOverall graft survivalPost-transplant surveillanceCardiac allograft vasculopathyHeart transplant patientsTomography myocardial perfusionRecent FindingsMultiple studiesMyocardial perfusion imagingMyocardial blood flowMBF quantificationGraft survivalHeart transplantationTransplant patientsTransplant rejectionSerial monitoringPrognostic performancePET myocardial blood flowBlood flowMyocardial perfusionPerfusion imagingMBF assessmentBlood flow quantification
2021
Association Between Impaired Myocardial Flow Reserve on 82Rubidium Positron Emission Tomography Imaging and Adverse Events in Patients With Autoimmune Rheumatic Disease
Feher A, Boutagy NE, Oikonomou EK, Liu YH, Miller EJ, Sinusas AJ, Hinchcliff M. Association Between Impaired Myocardial Flow Reserve on 82Rubidium Positron Emission Tomography Imaging and Adverse Events in Patients With Autoimmune Rheumatic Disease. Circulation Cardiovascular Imaging 2021, 14: e012208. PMID: 34503339, PMCID: PMC8475774, DOI: 10.1161/circimaging.120.012208.Peer-Reviewed Original ResearchConceptsAutoimmune rheumatic diseasesMyocardial flow reserveLower myocardial flow reserveCox regression analysisAdverse eventsARDS diagnosisIndependent predictorsRheumatic diseasesPerfusion defectsFlow reserveNormal myocardial flow reserveLeft ventricular ejection fractionEnd pointGlobal myocardial flow reserveImpaired Myocardial Flow ReserveComorbidity-matched patientsSevere coronary calcificationCombined end pointCoronary microvascular dysfunctionHeart failure admissionsComposite end pointEvent-free survivalFramingham risk scoreLarge perfusion defectsRetrospective cohort analysis
2020
Feasibility study of PET dynamic imaging of [18F]DHMT for quantification of reactive oxygen species in the myocardium of large animals
Wu J, Boutagy NE, Cai Z, Lin SF, Zheng MQ, Feher A, Stendahl JC, Kapinos M, Gallezot JD, Liu H, Mulnix T, Zhang W, Lindemann M, Teng JK, Miller EJ, Huang Y, Carson RE, Sinusas AJ, Liu C. Feasibility study of PET dynamic imaging of [18F]DHMT for quantification of reactive oxygen species in the myocardium of large animals. Journal Of Nuclear Cardiology 2020, 29: 216-225. PMID: 32415628, PMCID: PMC7666654, DOI: 10.1007/s12350-020-02184-3.Peer-Reviewed Original ResearchAnimalsDogsFeasibility StudiesHumansMyocardiumPositron-Emission TomographyReactive Oxygen SpeciesSuperoxides
2018
Serial Assessment of Coronary Flow Reserve by Rubidium-82 Positron Emission Tomography Predicts Mortality in Heart Transplant Recipients
Feher A, Srivastava A, Quail MA, Boutagy NE, Khanna P, Wilson L, Miller EJ, Liu YH, Lee F, Sinusas AJ. Serial Assessment of Coronary Flow Reserve by Rubidium-82 Positron Emission Tomography Predicts Mortality in Heart Transplant Recipients. JACC Cardiovascular Imaging 2018, 13: 109-120. PMID: 30343093, PMCID: PMC6461525, DOI: 10.1016/j.jcmg.2018.08.025.Peer-Reviewed Original ResearchMeSH KeywordsAgedCoronary Artery DiseaseFemaleFractional Flow Reserve, MyocardialHeart TransplantationHumansMaleMiddle AgedMyocardial Perfusion ImagingPositron-Emission TomographyPredictive Value of TestsProspective StudiesRadiopharmaceuticalsReproducibility of ResultsRubidium RadioisotopesTime FactorsTreatment OutcomeConceptsPositron emission tomographyLong-term prognostic valueSerial assessmentPET-2Pet-1Cause mortalityHT patientsPrognostic valueHigh CFRLow CFRRb positron-emission tomographyEmission tomographyRb-82 positron emission tomographyRubidium-82 positron emission tomographyPET imagingHeart transplantation patientsHistory of HTCardiac allograft vasculopathyHeart transplant recipientsLong-term mortalitySingle-center studyMultivariate Cox regressionCoronary flow reserveAllograft vasculopathyHT recipients
2017
Quantitative Assessment of Coronary Microvascular Function
Feher A, Sinusas AJ. Quantitative Assessment of Coronary Microvascular Function. Circulation Cardiovascular Imaging 2017, 10: e006427. PMID: 28794138, PMCID: PMC5678979, DOI: 10.1161/circimaging.117.006427.Peer-Reviewed Original ResearchMeSH KeywordsComputed Tomography AngiographyCoronary AngiographyCoronary CirculationEchocardiographyHeart DiseasesHumansMagnetic Resonance ImagingMicrocirculationMyocardial Perfusion ImagingPositron-Emission TomographyPredictive Value of TestsPrognosisReproducibility of ResultsTomography, Emission-Computed, Single-PhotonConceptsCoronary microvascular dysfunctionMyocardial blood flowMicrovascular dysfunctionBlood flowMyocardial perfusionCoronary microvascular impairmentCoronary microvascular functionEpicardial coronary arteriesNormal myocardial perfusionMyocardial contrast echocardiographyAbsolute myocardial blood flowImportant prognostic relevanceMagnetic resonance imagingPositron emission tomographySingle photon emissionMicrovascular impairmentMicrovascular functionMultiple imaging modalitiesPrognostic relevanceCoronary arteryCoronary flowCoronary perfusionContrast echocardiographyClinical valueFunctional microcirculation