Adverse cardiovascular events and cardiac imaging findings in patients on immune checkpoint inhibitors
Kwan J, Shen M, Akhlaghi N, Hu J, Mora R, Cross J, Jiang M, Mankbadi M, Wang P, Zaman S, Lee S, Im Y, Feher A, Liu Y, S. S, Tao W, Wei W, Baldassarre L. Adverse cardiovascular events and cardiac imaging findings in patients on immune checkpoint inhibitors. PLOS ONE 2024, 19: e0314555. PMID: 39621799, PMCID: PMC11611253, DOI: 10.1371/journal.pone.0314555.Peer-Reviewed Original ResearchConceptsAdverse cardiovascular eventsICI therapyCardiac magnetic resonanceIncreased risk of mortalityICI initiationIncreased riskRisk of mortalityCentral nervous systemVentricular dysfunctionCancer patients treated with ICIsCardiovascular eventsLeft ventricular late gadolinium enhancementMortality benefitCardiovascular riskAbnormal left ventricular ejection fractionPatients treated with ICIsLeft ventricular ejection fractionCentral nervous system malignanciesRisk of adverse cardiovascular eventsImmune checkpoint inhibitorsRight ventricular dysfunctionGlobal longitudinal strainVentricular ejection fractionLeft ventricular dysfunctionMultimodality cardiac imagingMulti-modality imaging for assessment of the microcirculation in peripheral artery disease: Bench to clinical practice
Callegari S, Feher A, Smolderen K, Mena-Hurtado C, Sinusas A. Multi-modality imaging for assessment of the microcirculation in peripheral artery disease: Bench to clinical practice. American Heart Journal Plus Cardiology Research And Practice 2024, 42: 100400. PMID: 38779485, PMCID: PMC11108852, DOI: 10.1016/j.ahjo.2024.100400.Peer-Reviewed Original ResearchPeripheral arterial diseaseMicrovascular diseasePeripheral microcirculationArtery diseaseEvaluation of response to therapyResponse to therapyManagement of peripheral arterial diseaseImprove risk stratificationOutcomes of peripheral artery diseaseAssessment of perfusionPathophysiology of peripheral arterial diseaseRisk of mortalityMolecular imaging studiesMulti-modal imagesPredictors of amputationRisk stratificationPre-clinicalImaging studiesClinical perfusionProcedural treatmentsClinical practicePersonalized managementMicrocirculationDiseasePerfusion