Arnaud Augert
Assistant ProfessorCards
About
Research
Publications
2025
MAX inactivation deregulates the MYC network and induces neuroendocrine neoplasia in multiple tissues
Freie B, Ibrahim A, Carroll P, Bronson R, Augert A, MacPherson D, Eisenman R. MAX inactivation deregulates the MYC network and induces neuroendocrine neoplasia in multiple tissues. Science Advances 2025, 11: eadt3177. PMID: 40279415, PMCID: PMC12024646, DOI: 10.1126/sciadv.adt3177.Peer-Reviewed Original Research
2021
Protein neddylation as a therapeutic target in pulmonary and extrapulmonary small cell carcinomas
Norton J, Augert A, Eastwood E, Basom R, Rudin C, MacPherson D. Protein neddylation as a therapeutic target in pulmonary and extrapulmonary small cell carcinomas. Genes & Development 2021, 35: 870-887. PMID: 34016692, PMCID: PMC8168556, DOI: 10.1101/gad.348316.121.Peer-Reviewed Original ResearchAnimalsBasic Helix-Loop-Helix Transcription FactorsCarcinoma, Small CellCell DeathCell Line, TumorCOP9 Signalosome ComplexCyclopentanesDisease Models, AnimalGene Expression Regulation, NeoplasticHeterograftsHumansLung NeoplasmsMiceNEDD8 ProteinNeuroendocrine CellsProteinsPyrimidinesRepressor ProteinsSequence Deletion
2020
MAX Functions as a Tumor Suppressor and Rewires Metabolism in Small Cell Lung Cancer
Augert A, Mathsyaraja H, Ibrahim A, Freie B, Geuenich M, Cheng P, Alibeckoff S, Wu N, Hiatt J, Basom R, Gazdar A, Sullivan L, Eisenman R, MacPherson D. MAX Functions as a Tumor Suppressor and Rewires Metabolism in Small Cell Lung Cancer. Cancer Cell 2020, 38: 97-114.e7. PMID: 32470392, PMCID: PMC7363581, DOI: 10.1016/j.ccell.2020.04.016.Peer-Reviewed Original ResearchAnimalsBasic Helix-Loop-Helix Leucine Zipper Transcription FactorsCells, CulturedDisease Models, AnimalGene Expression ProfilingGene Expression Regulation, NeoplasticHEK293 CellsHep G2 CellsHumansK562 CellsKaplan-Meier EstimateLung NeoplasmsMice, KnockoutMice, TransgenicSmall Cell Lung CarcinomaTumor Suppressor Proteins
2019
Targeting NOTCH activation in small cell lung cancer through LSD1 inhibition
Augert A, Eastwood E, Ibrahim A, Wu N, Grunblatt E, Basom R, Liggitt D, Eaton K, Martins R, Poirier J, Rudin C, Milletti F, Cheng W, Mack F, MacPherson D. Targeting NOTCH activation in small cell lung cancer through LSD1 inhibition. Science Signaling 2019, 12: eaau2922. PMID: 30723171, PMCID: PMC6530478, DOI: 10.1126/scisignal.aau2922.Peer-Reviewed Original ResearchAnimalsBasic Helix-Loop-Helix Transcription FactorsCell Line, TumorEnzyme InhibitorsGene Expression Regulation, NeoplasticHistone DemethylasesHumansKaplan-Meier EstimateLung NeoplasmsMice, Inbred NODMice, KnockoutMice, SCIDReceptors, NotchSignal TransductionSmall Cell Lung CarcinomaTumor BurdenXenograft Model Antitumor Assays
2018
Crebbp loss drives small cell lung cancer and increases sensitivity to HDAC inhibition
Jia D, Augert A, Kim D, Eastwood E, Wu N, Ibrahim A, Kim K, Dunn C, Pillai S, Gazdar A, Bolouri H, Park K, MacPherson D. Crebbp loss drives small cell lung cancer and increases sensitivity to HDAC inhibition. Cancer Discovery 2018, 8: cd-18-0385. PMID: 30181244, PMCID: PMC6294438, DOI: 10.1158/2159-8290.cd-18-0385.Peer-Reviewed Original ResearchAcetylationAnimalsCell MovementCell ProliferationCell Transformation, NeoplasticCREB-Binding ProteinDrug Resistance, NeoplasmEpithelial-Mesenchymal TransitionGene Expression Regulation, NeoplasticHistone Deacetylase InhibitorsHistone DeacetylasesHumansLung NeoplasmsMiceMice, KnockoutMutationRetinoblastoma ProteinSmall Cell Lung CarcinomaTumor Cells, CulturedTumor Suppressor Protein p53
2016
Small Cell Lung Cancer Exhibits Frequent Inactivating Mutations in the Histone Methyltransferase KMT2D/MLL2: CALGB 151111 (Alliance)
Augert A, Zhang Q, Bates B, Cui M, Wang X, Wildey G, Dowlati A, MacPherson D. Small Cell Lung Cancer Exhibits Frequent Inactivating Mutations in the Histone Methyltransferase KMT2D/MLL2: CALGB 151111 (Alliance). Journal Of Thoracic Oncology 2016, 12: 704-713. PMID: 28007623, PMCID: PMC5669801, DOI: 10.1016/j.jtho.2016.12.011.Peer-Reviewed Original ResearchThe PLA2R1-JAK2 pathway upregulates ERRα and its mitochondrial program to exert tumor-suppressive action
Griveau A, Devailly G, Eberst L, Navaratnam N, Le Calvé B, Ferrand M, Faull P, Augert A, Dante R, Vanacker J, Vindrieux D, Bernard D. The PLA2R1-JAK2 pathway upregulates ERRα and its mitochondrial program to exert tumor-suppressive action. Oncogene 2016, 35: 5033-5042. PMID: 27041564, DOI: 10.1038/onc.2016.43.Peer-Reviewed Original Research
2015
Multidrug resistance protein 3 loss promotes tumor formation by inducing senescence escape
Wiel C, Gras B, Vindrieux D, Warnier M, Gitenay D, Le Calvé B, Ferrand M, Augert A, Bernard D. Multidrug resistance protein 3 loss promotes tumor formation by inducing senescence escape. Oncogene 2015, 35: 1596-1601. PMID: 26073088, DOI: 10.1038/onc.2015.218.Peer-Reviewed Original Research
2014
Treating Transcriptional Addiction in Small Cell Lung Cancer
Augert A, MacPherson D. Treating Transcriptional Addiction in Small Cell Lung Cancer. Cancer Cell 2014, 26: 783-784. PMID: 25490443, DOI: 10.1016/j.ccell.2014.11.012.Peer-Reviewed Original ResearchEndoplasmic reticulum calcium release through ITPR2 channels leads to mitochondrial calcium accumulation and senescence
Wiel C, Lallet-Daher H, Gitenay D, Gras B, Le Calvé B, Augert A, Ferrand M, Prevarskaya N, Simonnet H, Vindrieux D, Bernard D. Endoplasmic reticulum calcium release through ITPR2 channels leads to mitochondrial calcium accumulation and senescence. Nature Communications 2014, 5: 3792. PMID: 24797322, DOI: 10.1038/ncomms4792.Peer-Reviewed Original Research
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