2020
Gene-environment interaction promotes Alzheimer's risk as revealed by synergy of repeated mild traumatic brain injury and mouse App knock-in
Chiasseu M, Fesharaki-Zadeh A, Saito T, Saido TC, Strittmatter SM. Gene-environment interaction promotes Alzheimer's risk as revealed by synergy of repeated mild traumatic brain injury and mouse App knock-in. Neurobiology Of Disease 2020, 145: 105059. PMID: 32858147, PMCID: PMC7572902, DOI: 10.1016/j.nbd.2020.105059.Peer-Reviewed Original ResearchConceptsMild traumatic brain injuryTraumatic brain injuryAlzheimer's diseaseBrain injuryGene-environment interactionsMild closed head injuryMorris water maze testAge-matched wild-type controlsStrong unmet needAccumulation of amyloidAge-matched miceClosed head injuryWater maze testNovel object recognitionPersistent cognitive deficitsProtein gene mutationsIba1 expressionWild-type controlsPhospho-tauClinical manifestationsAD pathologyAD symptomsHead injuryAD pathogenesisRisk factors
2019
Chronic Traumatic Encephalopathy: A Brief Overview
Fesharaki-Zadeh A. Chronic Traumatic Encephalopathy: A Brief Overview. Frontiers In Neurology 2019, 10: 713. PMID: 31333567, PMCID: PMC6616127, DOI: 10.3389/fneur.2019.00713.Peer-Reviewed Original ResearchChronic traumatic encephalopathyTraumatic brain injuryRepetitive mild traumatic brain injuryPost-traumatic brain injuryMild traumatic brain injuryPeri-vascular regionsRisk factor genesAmerican football playersTraumatic encephalopathyAPOE4 carriersSubtle presentationBrain injuryTBI treatmentTeam physiciansNeuropathological signatureNeuropsychiatric assessmentPhosphorylated tauCognitive impairmentCombat settingNeurodegenerative diseasesDiseaseMilitary veteransDistinct phenotypesSubtypesFootball players