Early Life Stress Inhibits Expression of a Novel Innate Immune Pathway in the Developing Hippocampus
Wei L, Simen A, Mane S, Kaffman A. Early Life Stress Inhibits Expression of a Novel Innate Immune Pathway in the Developing Hippocampus. Neuropsychopharmacology 2011, 37: 567-580. PMID: 21993208, PMCID: PMC3242319, DOI: 10.1038/npp.2011.239.Peer-Reviewed Original ResearchMeSH KeywordsAcute-Phase ProteinsAnimalsAnimals, NewbornAnxietyBehavior, AnimalCarrier ProteinsCorticosteroneCritical Period, PsychologicalDisease Models, AnimalDown-RegulationFemaleGenomicsHippocampusHumansImmunity, InnateMaleMaternal DeprivationMembrane GlycoproteinsMemory DisordersMiceMice, Inbred BALB CMice, KnockoutNeurogenesisStress, PsychologicalConceptsLipopolysaccharide binding proteinEarly life stressAnxiety-like behaviorLife stressSynaptic pruningNovel innate immune pathwayLBP knockout miceNormal hippocampal developmentNormal synaptic pruningSynaptic marker PSD95Hippocampus of pupsMajor risk factorChronic mental illnessImpairs cognitive functionInnate immune pathwaysPostnatal day 30Hippocampal-dependent memoryAbnormal spine morphologyInnate immune systemNon-human primatesLBP levelsSpine densityMicroglia cellsRisk factorsHippocampal developmentAffiliative Behavior Requires Juvenile, But Not Adult Neurogenesis
Wei L, Meaney MJ, Duman RS, Kaffman A. Affiliative Behavior Requires Juvenile, But Not Adult Neurogenesis. Journal Of Neuroscience 2011, 31: 14335-14345. PMID: 21976519, PMCID: PMC3204413, DOI: 10.1523/jneurosci.1333-11.2011.Peer-Reviewed Original ResearchConceptsAdult female miceAdult neurogenesisFemale miceSubventricular zoneAblation of neurogenesisLevels of neurogenesisTransgenic mouse approachSubgranular zoneOlfactory deficitsNew neuronsGlobal eliminationBrain circuitsNeurogenesisProfound impairmentMiceJuvenile periodNovel roleAdult femalesSocial explorationMouse approachSocial abnormalitiesMolecular mechanismsAblationFemalesPeriod